6-OHDA induced Mouse Model Development Service

The 6-OHDA-induced mouse model is a widely used preclinical model for Parkinson's disease (PD) research. 6-OHDA selectively damages dopaminergic neurons, mimicking the neurodegeneration seen in PD. Cited literature demonstrates its value in studying disease mechanisms, evaluating potential therapies, and understanding PD pathophysiology. This model, when expertly applied, provides critical insights for advancing PD research. Our 6-OHDA-Induced Mouse Model service helps you accelerate your research through our expertise in model generation, comprehensive characterization, and customized study design.

How Our 6-OHDA-Induced Mouse Model Can Assist Your Project?

Creative Biolabs' 6-OHDA-Induced Mouse Model service provides you with a robust and reliable platform for your PD research. We deliver fully characterized animal models and comprehensive data packages to support your drug discovery and preclinical studies.

Workflow

Our streamlined workflow ensures efficient and high-quality model generation and data acquisition.

• Required Starting Materials: To initiate a project, clients typically provide us with:
  • Detailed study objectives, including specific research questions and endpoints.
  • Test compounds or therapies to be evaluated (if applicable).
  • Any specific requirements for animal characteristics (e.g., strain, age).
• Final Deliverables: You will receive a comprehensive study report, including:
  • Detailed experimental protocol and methodology.
  • Raw and analyzed data from behavioral assessments and tissue analysis.
  • High-quality images and histological findings.
• Estimated Timeframe: The typical timeframe for this service ranges from 8 to 16 weeks, depending on the specific study design, the number of experimental groups, and the complexity of the required assessments.

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Why Choose Us?

Creative Biolabs is your trusted partner for preclinical PD research. We offer several key advantages:

• Expertise: Our team comprises experienced neuroscientists and animal model specialists with extensive knowledge of PD and the 6-OHDA model.
• Customization: We tailor our services to your specific research needs, offering flexible study designs and a wide range of endpoints.
• Quality: We adhere to the highest standards of animal care and experimental rigor, ensuring the reliability and reproducibility of our results.
• Comprehensive Solutions: We provide end-to-end services, from model generation to data analysis, streamlining your research process.
• Proven Track Record: Our clients experience an average increase in study efficiency and a reduction in research costs.

6-OHDA-Induced Mouse Model

6-OHDA model involves injecting the neurotoxin 6-OHDA into specific brain regions, selectively destroying dopaminergic neurons and resulting in PD-like motor symptoms. This model is widely used to investigate disease pathophysiology, evaluate neuroprotective strategies, and assess potential therapeutic interventions.

Fig.1 Dose-dependent damage of 6-OHDA in the nigrostriatal system of mice.¹

Fig.2 Motor behavioural assessment of 6-OHDA degree of lesion.¹

Customer Reviews

"Using Creative Biolabs' 6-OHDA model in our research has significantly improved the accuracy and reliability of our preclinical studies. The detailed characterization and comprehensive data package were invaluable." - [Time], J***es

" Creative Biolabs' expertise in 6-OHDA model generation and behavioral assessments has greatly facilitated our drug discovery efforts. The customization options allowed us to precisely address our research questions." - [Time], M***er

" Creative Biolabs' 6-OHDA model allowed us to effectively evaluate the neuroprotective potential of our compound. The clear reporting and fast turnaround time accelerated our project timeline." - [Time], E***y

What We Can Offer

We offer a comprehensive 6-OHDA-Induced Mouse Model service, providing you with:

• A one-stop service, from initial study design to final data analysis and reporting.
• Efficient upstream and downstream process development tailored to your specific research goals.
• The ability to work with various study scales, accommodating both small pilot studies and large-scale preclinical trials.
• A well-established quality system, incorporating Quality-by-Design (QbD) principles and process analytical techniques (PAT) to ensure data reliability.
• Strict aseptic verification procedures throughout the model generation process.
• Customizable protocols to meet your unique research needs.
• Rigorous quality control tools to quantify and evaluate the integrity of the model and the data.
• Detailed documentation of strain origin, assessed and approved by our quality assurance service.
• Guaranteed stability of our model.
• Optimization of experimental conditions to maximize the relevance of your study.
• Adherence to high ethical and animal welfare standards.

Related Services

Creative Biolabs offers a range of complementary services to support your neuroscience research:

• Custom Antibody Development: We provide tailored antibody solutions for your specific research needs.
• Cell Line Engineering: We offer cell line modification services to create models.
• Histopathology Services: Detailed tissue analysis to complement your in vivo studies.

For more information about our 6-OHDA-Induced Mouse Model service and to discuss your specific project needs, please contact our team.

FAQs

Here are some frequently asked questions about Creative Biolabs' 6-OHDA-Induced Mouse Model service:

Reference

1. Cui, Juntao, et al. "Characterization of graded 6-Hydroxydopamine unilateral lesion in medial forebrain bundle of mice." Scientific reports 14.1 (2024): 3721. Distributed under Open Access license CC BY 4.0, without modification.