Neuroprotective Agent Screening Service

Screening neuroprotective agents is a crucial step in the pursuit of treatments for neurodegenerative diseases. By screening compounds with different mechanisms of action, researchers can identify new therapeutic targets and ultimately develop new drugs that can improve the quality of life of patients. To learn more about our products and services, submit a project inquiry, or request a quote, please contact us.

Introduction

The importance of neuroprotectant screening lies in the identification of compounds that can safeguard neurons from damage, thus offering prospective drug candidates for the management of neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis (MS), which are typified by the progressive loss and dysfunction of neurons.

Available Assays for Neuroprotective Agent Screening

• iPSC Cell-Based Screening Models

Our scientists have developed several iPSC-based neuroprotective drug screening models with high throughput and low turnaround times. Please click on your disease of interest for more information.

• High Throughput Screening (HTS)

The combination of iPSCs with high-throughput imaging technology allows for the efficient screening of compounds in vitro, thereby reducing the cost of preclinical research and animal experiments. Furthermore, HTS can be employed to identify potential drug targets that affect neuronal function and to verify screening results by analyzing changes in gene expression.

Fig.1 In vivo dopamine neuron imaging-based high throughput screening in larval zebrafish identifies potential neuroprotective compounds.¹

• Mitochondrial Health Screening

Our team of experts has developed a screening system that uses microscopy to track number, shape, and other health indicators, in neuronal mitochondria. This system is ideal for preclinical screening of compounds with potential for promoting mitochondrial health and for screening for mitochondrial toxins useful in research.

• Screening of Natural Products and Approved Pharmaceuticals

At Creative Biolabs, we also focus on compounds derived from natural products and FDA-approved drug libraries. For example, the NINDS custom library was used to screen for compounds that can prevent hair cell loss caused by aminoglycosides. By screening FDA-approved drug libraries, we aim to identify drugs with neuroprotective effects that have reduced regulatory barriers to further development.

Our cutting-edge research on neuroprotectants and professional screening services can help you achieve breakthroughs in the treatment of neurodegenerative diseases. Please contact us to discuss your project plan in detail.

Reference

1. Kim, Gha-hyun J., et al. "In vivo dopamine neuron imaging-based small molecule screen identifies novel neuroprotective compounds and targets." Frontiers in Pharmacology 13 (2022): 837756. Distributed under Open Access license CC BY 4.0, without modification.