Custom NeuroAntibody Development Service

Facilitating breakthroughs in neuroscience demands exceptionally tailored molecular probes. We provide comprehensive custom antibody generation services, encompassing the full developmental pipeline. This integrated process initiates with rigorous antigen design—including in silico modeling and synthesis—progresses through antibody production methodologies, and culminates in meticulous purification and stringent validation assays. Our seasoned scientific cadre, possessing over twenty years of dedicated experience, demonstrates proven efficacy in prosecuting even recalcitrant targets; indeed, this includes antigens historically resistant to conventional cloning and expression paradigms. The resultant high-fidelity antibodies are engineered to empower precise investigations into fundamental neuronal functions, intricate signaling cascades, and the underlying pathophysiology of diverse nervous system disorders. For detailed specifications regarding available services, consultation on bespoke project requirements, or pertinent pricing structures, please submit a formal inquiry.

Neuroscience Target Portfolio

Our neuroscience target portfolio encompasses a broad spectrum, including neuronal function, synaptic plasticity, neurodegenerative disease-related proteins (e.g., Tau, β-amyloid), and blood-brain barrier markers. We have achieved notable success in developing highly specific antibodies against Tau protein phosphorylation sites and β-amyloid protein isomers, crucial for pathological mechanism research. Furthermore, our expertise in antigen design optimization, encompassing transmembrane domain modification and glycosylation simulation, enables us to effectively address complex targets, such as NMDA receptors.

Comprehensive Custom Antibody Development

We offer a complete, tailored service for generating high-quality antibodies targeting neural antigens, encompassing:

	Precise Antigen Design
	Utilizing bioinformatics and structural analysis, we create optimal immunogens (recombinant proteins, peptides, or cell membrane antigens) for effective antibody generation.
	Flexible Antibody Production
	Employing diverse host species (mice, rats, rabbits, alpacas) and advanced technologies (hybridoma, phage display, single B cell cloning) to meet specific project needs.
	Rigorous Quality Assurance
	Ensuring antibody specificity and affinity through SPR analysis, epitope mapping via mass spectrometry, and thorough cross-reactivity testing (including brain tissue lysate).
	Dedicated Neural Validation
	Providing comprehensive validation data using brain slice IHC, primary neuron IF, cerebrospinal fluid ELISA, and other relevant neural assays.

Custom Antibody Service Options

We offer a wide range of antibody production options to meet your research needs, leveraging diverse host species and cutting-edge technologies. We tailor our approach to ensure optimal antibody generation for your specific application.

High Throughput Recombinant Antibody Production	Recombinant Ab Production	Monoclonal Ab Production	Polyclonal Ab Production
Modified Ab Production	Anti-idiotype Antibody Production	Single B Cell Antibody Discovery	Mammalian Cell Display Service

Case Study

Our antibody products are manufactured to exacting quality control standards, including high purity, specificity, and stability, to ensure their reliability and effectiveness in scientific research applications.

Antibody Binding Capacity Tests

In addition to our standard quality control procedures, we can also customize special quality control requirements to suit your specific needs.

	Anti-Human SNCA Therapeutic Antibody (NRP-0422-P614) in WB Western blot analysis of NRP-0422-P614 was performed by loading human recombinant alpha-synuclein protein. NRP-0422-P614 incubation concentration: 2 ng/μL. The secondary antibody: HRP-Anti-Mouse IgG (H+L) Lane 1: Reducing Antigen (0.1 μg) Lane 2: Reducing Antigen (0.3 μg) Lane 3: Reducing Antigen (0.6 μg)
	Anti-Human SNCA Therapeutic Antibody (NRP-0422-P614) in ELISA ELISA analysis of NRP-0422-P614 was performed by coating with human recombinant alpha-synuclein protein. The secondary antibody: HRP-Anti-Mouse IgG (H+L)

For detailed elucidation regarding project-specific requirements and the subsequent generation of a bespoke proposal, please initiate direct contact.

Reference

1. Frenzel, André, Michael Hust, and Thomas Schirrmann. "Expression of recombinant antibodies." Frontiers in immunology 4 (2013): 217. Distributed under Open Access license CC BY 4.0, without modification.