DEPTAC [Tau Dephosphorylation]
Selectively promoting tau removal in tauopathies.
- Species:
- Human
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Description
Creative Biolabs offers a novel dephosphorylation targeting chimera (DEPTAC) to specifically promote the binding of tau to Bα subunit-containing protein phosphatase 2A (PP2A-Bα), the most active tau phosphatase in the brain. DEPTAC is highly efficient in dephosphorylating tau at multiple AD-associated sites and preventing tau accumulation in vitro and in vivo.
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