iNeuMab™ Anti-Tau (K280-ac) Antibody (NRP-0422-P1744)

Q: How well does this antibody recognize Tau protein in human samples compared to mouse samples?

The antibody has been validated for use in human, mouse, and rat samples. It shows strong specificity and sensitivity across these species. It is particularly effective in detecting acetylated forms of Tau in human samples, which is crucial for studies related to human neurodegenerative diseases.

Q: Are there any known cross-reactivities of this antibody with other proteins?

The antibody is highly specific for the acetylated K280 epitope of the Tau protein, with minimal cross-reactivity with other proteins. This specificity is crucial for accurate detection in complex samples. However, we recommend validating the antibody in your specific application to confirm its specificity in your experimental context.

Q: How can I be sure of the antibody’s specificity for acetylated Tau versus other post-translational modifications?

The antibody is specifically designed to recognize the K280-acetylated form of Tau, ensuring high specificity. Validation studies, including peptide competition assays, confirm that the antibody selectively binds to acetylated epitopes without significant cross-reactivity to other post-translational modifications, such as phosphorylation.

Product Overview

Description

The anti-tau antibody specifically binds to tau protein in which the 280 thlysine is acetylated, and can inhibit the aggregation of abnormal tau protein. The anti-tau antibody is administered to an animal model that causes dementia, it is possible to improve the motor ability and cognitive ability of the animal model. Therefore, the anti-tau antibody according to the present invention can be usefully used in the prevention or treatment of neurodegenerative diseases.

Species Reactivity

Human; Mouse

Clonality

Monoclonal

Host Species

Mouse

Applications

ELISA; Block; Inhib; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

> 95% (SDS-PAGE)

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

Tau(K280-ac)

Official Name

Tau (K280-ac)

Alternative Names

MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins; tau-40; phosphorylated tau

Gene ID

4137(Human); 17762(Mouse); 29477(Rat)

Uniprot ID

P10636(Human); P10637(Mouse); P19332(Rat)

Publications

Publications (0)

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Scientific Resources

[Brochure]

Neuros Antibody Product Panel

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Customer Reviews and Q&As

Customer Reviews Average Customer Ratings Overall

5.0

Excellent

We've been using the antibody in our lab for over six months now

We primarily use it for blocking experiments, and the results have been reproducible every time. The antibody's high affinity ensures that we get clear, specific staining without background noise. This has significantly improved our workflow efficiency.

Excellent

As a neuroscientist, having reliable antibodies is crucial for my work

The NeuroMab antibodies' performance in both ELISA and immunoblotting has been outstanding. The antibody binds specifically to its target without cross-reactivity, making our data robust and reproducible.

Excellent

A staple in our lab

Its performance in blocking and inhibition assays has been particularly impressive. The consistent quality of the antibody has allowed us to publish several high-impact papers. It's a reliable tool for any lab studying tau proteins.

Excellent

It's a reliable and high-quality product

Its high specificity and reproducibility have made it our go-to antibody for tau protein studies. The quality control of NeuroMab products is evident in the consistent performance of this antibody.

Excellent

A critical tool in our lab's research on tauopathies

The antibody's specificity for the K280-acetylated form of tau is impressive, and it has performed well in both our in vitro and in vivo experiments. Highly recommended.

Q&As

How well does this antibody recognize Tau protein in human samples compared to mouse samples?

The antibody has been validated for use in human, mouse, and rat samples. It shows strong specificity and sensitivity across these species. It is particularly effective in detecting acetylated forms of Tau in human samples, which is crucial for studies related to human neurodegenerative diseases.

Are there any known cross-reactivities of this antibody with other proteins?

The antibody is highly specific for the acetylated K280 epitope of the Tau protein, with minimal cross-reactivity with other proteins. This specificity is crucial for accurate detection in complex samples. However, we recommend validating the antibody in your specific application to confirm its specificity in your experimental context.

How can I be sure of the antibody’s specificity for acetylated Tau versus other post-translational modifications?

The antibody is specifically designed to recognize the K280-acetylated form of Tau, ensuring high specificity. Validation studies, including peptide competition assays, confirm that the antibody selectively binds to acetylated epitopes without significant cross-reactivity to other post-translational modifications, such as phosphorylation.