NeuroMab™ Anti-SOD1 Antibody(NRP-0422-P648)

Product Overview

Description

The human anti-SOD1 antibody is useful for treating diseases associated with misfolded / aggregated SOD1, such as ALS (ALS).

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Human

Applications

ELISA; FC; IHC; In Vitro; In Vivo

Relevant Diseases

Amyotrophic Lateral Sclerosis

Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only

Target

SOD1

Official Name

SOD1

Full Name

superoxide dismutase 1

Alternative Names

SOD1; ALS; ALS1; HEL-S-44; IPOA; SOD; hSod1; homodimer; superoxide dismutase 1; soluble; superoxide dismutase 1; STAHP

Product Pictures

ELISA

Figure 1 Binding specificity of human antibody to human recombinant SOD1.

h3D6v2 was as effective as chimeric 3D6 in inducing phagocytosis of Aβ aggregates in PDAPP mouse brain tissue. IgG is used as a negative control in this experiment because it cannot bind Aβ and therefore cannot induce phagocytosis.

ELISA

Figure 3 Antibodies preferentially bind misfolded/aggregated human SOD1.

ELISA

Figure 2 Binding specificity of human antibody to human recombinant SOD1.

IHC

Figure 4 NI-204.12G7 showed prominent SOD1 pathological staining, including cytoplasmic SOD1 inclusions (mainly in motor neurons) and extracellular SOD1 aggregates.

Publications