Mouse Anti-Human MMP-3 Monoclonal Antibody (CBP3876)

Product Overview

Description

MMP3 is a member of the matrix metalloproteinase family proteins (MMPs).MMP3 consists of a prodomain that is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region, and a carboxyl terminal (hemopexin-like repeats) domain. Substrates of MMP3 include collagen α chains, aggrecan, laminin, fibronectin, elastin, casein, α1-antitrypsin, myelin basic protein, IL1β, IGFBP3, pro MMP1, pro MMP7, pro MMP8, pro MMP9, and pro MMP13. MMP3 is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation.

Immunogen

Recombinant human MMP-3, amino acids Tyr18-Cys477, was expressed with N-terminal His9-SGGGSGGGIEGR tag in 293E cells.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG1, κ

Clone Number

CBP3876

Applications

Application Notes

WB (0.5-2.5 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

MMP-3

Official Name

MMP3

Full Name

Matrix metalloproteinase-3

Alternative Names

MMP3; CHDS6; MMP-3; SL-1; STMY; STMY1; STR1; matrix metallopeptidase 3

Gene ID

4314 (Human); 17392 (Mouse)

Uniprot ID

P08254 (Human); P28862 (Mouse)

References

1. Nagase H and Woessner JF Jr. 1999. J. Biol. Chem. 274:21491.
2. Boire A, et al. 2005. Cell 120:303.
3. Kader AK, et al. 2007. Clin. Cancer Res. 13:2614.
4. Gill SE and Parks WC. 2008. Int. J. Biochem. Cell Biol. 40:1334.
5. Mazor R, et al. 2013. J. Biol. Chem. 288:598.
6. Sommer K, et al. 2013. PLos One 8:e73992.

Publications