Product
Anti-Tau 425-441 Monoclonal Antibody (CBP4016)
[CAT#: NAB20121030LS]
Anti-Tau 425-441 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human; Mouse
- Applications:
- WB; IHC-P
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Tau proteins are microtubule-associated protein (MAPs) which are abundant in neurons of the central nervous system, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes and elsewhere. One of Tau's main functions is to modulate the stability of axonal microtubules. Tau is active primarily in the distal portions of axons providing microtubule stabilization as well as flexibility. Tau forms aggregates with specific structural properties referred to as Paired Helical Filaments (PHFs) that are a characteristic of many different types of dementias, known as tauopathies.
Immunogen
Recombinant C-terminal fragment of human 4R Tau protein encompassing amino acid residues 425-441.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2b, κ
Clone Number
CBP4016
Applications
WB; IHC-P
Application Notes
WB (1.0-5.0 µg/mL); IHC-P (2.0-5.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation; Neurodegeneration
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
Tau 425-441
Official Name
Tau 425-441
Full Name
Tau 425-441
Alternative Names
MAPT; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU; microtubule associated protein tau; Tau proteins
References
1. Augustinack JC, et al. 2002. Acta Neuropathol. 103(1):26-35. PubMed.
2. Seubert P, et al. 1995. J Biol Chem. 270(32):18917-22.PubMed.
3. Dong Y, et al. 2012. PLoS One 7(6):e39386. PubMed.
2. Seubert P, et al. 1995. J Biol Chem. 270(32):18917-22.PubMed.
3. Dong Y, et al. 2012. PLoS One 7(6):e39386. PubMed.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
