MicroRNAs

MicroRNAs (miRNAs) are a class of small, non-coding RNAs that have emerged as master regulators of gene expression. By binding to target mRNAs, they play pivotal roles in virtually every biological process. Their dysregulation is a hallmark of numerous human diseases, making them high-value targets for both biomarker discovery and therapeutic intervention. At Creative Biolabs, we are dedicated to empowering your miRNA research with a world-class portfolio of tools and expert services, designed to accelerate your journey from initial discovery to functional validation.

Fig.1 MicroRNA biogenesis and function. (OA Literature) Fig.1 MiRNA biogenesis and function.¹

Our Unrivaled miRNA Product Portfolio

1. Tools for Functional Analysis (Gain & Loss-of-Function):

Directly manipulate cellular miRNA levels with our high-purity synthetic oligonucleotides.

miRNA Mimics: For robust gain-of-function studies.
miRNA Inhibitors: For effective loss-of-function analysis.
Agomirs & Antagomirs: Advance your research in vivo with our expertly engineered, chemically modified mimics (Agomirs) and inhibitors (Antagomirs), designed for enhanced stability and cellular uptake.
miRNA Precursors: Utilize synthetic or vector-encoded pre-miRNA sequences for a more biologically native approach to studying miRNA processing and function.

2. Vector-Based Systems for Stable Modulation & Analysis:

For long-term studies and in-depth mechanistic validation, we offer a complete suite of custom vectors:

Overexpression & Sponge Vectors: For stable miRNA gain- or loss-of-function.
Activity Sensor & 3'UTR Validation Vectors: Utilize our advanced dual-luciferase reporter system to monitor endogenous miRNA activity or definitively validate direct miRNA-target interactions.

3. High-Throughput Screening Libraries:

Accelerate large-scale functional genomics or drug discovery with our comprehensive Mimic, Inhibitor, Agomir, Antagomir and Precursor for human, mouse, and rat, covering various miRBase versions.

4. Accurate Quantification Kits & Reagents:

Quantify miRNA expression with unparalleled precision and flexibility. Choose between:

Bulge-Loop qRT-PCR Kit: For exceptional, single-nucleotide specificity, ideal for distinguishing highly similar miRNAs.
Poly(A) Tailing qRT-PCR Kit: A universal system for high-throughput profiling of numerous miRNAs from a single sample. We also provide standalone primer sets.

5. Rigorous Experimental Controls:

We understand that robust data requires impeccable controls. We offer an extensive selection of negative controls for mimics, inhibitors, agomirs, and antagomirs. These are available in multiple scrambled sequences (e.g., #19, #22, #24) and with various fluorescent labels (FAM, Cy3, Cy5) to monitor transfection efficiency and rule out non-specific effects.

From Products to Partnership: Our End-to-End miRNA Research Services

Beyond providing best-in-class products, Creative Biolabs operates as your full-service research partner. Leverage our expert team and state-of-the-art facility to execute your entire miRNA research project. Our integrated service platform follows a proven workflow to ensure high-quality, consistent data while accelerating your timeline.

Our comprehensive service pipeline includes:

Fig.2 miRNA Service Workflow. (Creative Biolabs Original)

Unrivaled Coverage & Customization

Our commitment is to provide the most comprehensive resources. Our pre-designed product catalog covers all human, mouse, and rat miRNAs listed in the latest miRBase database. For unique research needs, our expert team provides fully customized synthesis for miRNA mimics and inhibitors from other species or for novel sequences not yet curated in miRBase, ensuring you are never limited by catalog availability.

Begin Your miRNA Discovery Today

Whether you need a specific reagent or a full-service research partner, Creative Biolabs has the solution. Explore our catalog or consult our experts to design a custom service plan. Partner with us to unlock the full potential of miRNA biology.

Reference

Zhang, Jingdan et al. "Role and regulatory mechanism of microRNA mediated neuroinflammation in neuronal system diseases." Frontiers in immunology vol. 14 1238930. 11 Aug. 2023, doi:10.3389/fimmu.2023.1238930. Distributed under Open Access License CC BY 4.0 without modification.

For Research Use Only. Not For Clinical Use.

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