Rat Anti-Human Cytokeratin 6 Monoclonal Antibody (CBP2467)

Product Overview

Description

Keratins are main structural proteins of epithelial cells and form a cytoplasmic intermediate filament network, which is required for cell integrity and protecting cells from stress or injury. Keratin 6 (KRT6), also known as cytokeratin-6 or CK-6, is a type II intermediate filament protein constitutively expressed in all major types of epithelial appendages, such as hair, nail, and glands. Expression of KRT6 is induced by cell injury, infection, and disease. KRT6 has been identified as a marker of mammary gland progenitor cells. Defects in KRT6 genes have been associated with the inherited disorder pachyonychia congenital (PC), leading to structural abnormalities of nail, palms, and soles.

Immunogen

Human cytokeratin 6A peptide (2-18 a.a.) conjugated to KLH

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG2a, κ

Clone Number

CBP2467

Applications

WB; ICC

Application Notes

WB (0.1- 1 µg/mL); ICC (0.1- 1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

Batch Dependent

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Cytokeratin 6

Official Name

Cytokeratin 6

Full Name

Cytokeratin 6

Alternative Names

Keratin; type II cytoskeletal 6; Cytokeratin-6; CK-6; Keratin-6; KRT6

References

1. Arumugam A, et al. 2014. Biochem. Biophys. Res. Commun. 451:394.
2. Cao L, et al. 2010. J. Appl. Toxicol. 30:416.
3. Gu LH, Coulombe PA. 2008. Am. J. Pathol. 173:752.
4. Wong P, Coulombe PA. 2003. J. Cell Biol. 163:327.

Publications