Product
Rat Anti-Human Cytokeratin 6 Monoclonal Antibody (CBP2467)
[CAT#: NAB2010573LS]
Anti-Cytokeratin 6 Monoclonal Antibody
- Host Species:
- Rat
- Species Reactivity:
- Human
- Applications:
- WB; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
Keratins are main structural proteins of epithelial cells and form a cytoplasmic intermediate filament network, which is required for cell integrity and protecting cells from stress or injury. Keratin 6 (KRT6), also known as cytokeratin-6 or CK-6, is a type II intermediate filament protein constitutively expressed in all major types of epithelial appendages, such as hair, nail, and glands. Expression of KRT6 is induced by cell injury, infection, and disease. KRT6 has been identified as a marker of mammary gland progenitor cells. Defects in KRT6 genes have been associated with the inherited disorder pachyonychia congenital (PC), leading to structural abnormalities of nail, palms, and soles.
Immunogen
Human cytokeratin 6A peptide (2-18 a.a.) conjugated to KLH
Species Reactivity
Human
Clonality
Monoclonal
Host Species
Rat
Isotype
IgG2a, κ
Clone Number
CBP2467
Applications
WB; ICC
Application Notes
WB (0.1- 1 µg/mL); ICC (0.1- 1.0 µg/mL)
Relevant Diseases
Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes
Research Areas
Neuroinflammation
Conjugation
Unconjugated
Product Properties
Form
Liquid
Formulation
PBS, pH 7.2, containing 0.09% sodium azide.
Concentration
Batch Dependent
Purification
Affinity chromatography
Purity
>95%, as determined by Coomassie stained SDS-PAGE.
Shipping
The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.
Storage
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Handling Advice
Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.
Research Use Only
For research use only, not for diagnostic or therapeutic use.
Target
Target
Cytokeratin 6
Official Name
Cytokeratin 6
Full Name
Cytokeratin 6
Alternative Names
Keratin; type II cytoskeletal 6; Cytokeratin-6; CK-6; Keratin-6; KRT6
References
1. Arumugam A, et al. 2014. Biochem. Biophys. Res. Commun. 451:394.
2. Cao L, et al. 2010. J. Appl. Toxicol. 30:416.
3. Gu LH, Coulombe PA. 2008. Am. J. Pathol. 173:752.
4. Wong P, Coulombe PA. 2003. J. Cell Biol. 163:327.
2. Cao L, et al. 2010. J. Appl. Toxicol. 30:416.
3. Gu LH, Coulombe PA. 2008. Am. J. Pathol. 173:752.
4. Wong P, Coulombe PA. 2003. J. Cell Biol. 163:327.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
