Animal Models for Neurological Disorders
Animal models are important and indispensable in neuroscience because these models greatly contribute to the translational process of neurotherapeutic development and preclinical drug trials. They help the elucidation of the pathomechanism of various neurological diseases, such as stroke, anxiety, depression, dementia, Alzheimer’s disease (AD), Parkinson’s disease (PD), multiple sclerosis, and drug addiction. Moreover, they help the novel therapy and drug discovery of brain disorders.
Significance of Animal Models
Neurological diseases are intricate and may involve complicated mechanisms. To better understand the occurrence, progression and treatment of neurological diseases, scientists usually interrogate organisms at multiple levels: molecules, cells, tissues, organs, and physiological functions. In vitro approaches, such as cell line culture, iPSCs and organoid, can mimic the 3D and complex structures of tissue and organs. However, their use in neuroscience remains extremely limited due to the complex and interconnected structure of the brain. Animals, especially mammals, share striking anatomical and physiological similarities with humans. Therefore, animal models have prompted neuroscientists to comprehend the complex brain interaction network and understand the mechanism of neurological disorders.
Common Animals Used in the Research of Neurological Disorders
By mimicking the occurrence of neurological diseases, multiple animal models have been used to obtain more accurate information about the disease, as well as its prevention, diagnosis, and therapy. Moreover, scientists can carry out preclinical experiments that would be impractical or ethically prohibited with humans. With the progress of modeling technology, a number of different animals have been modeled for the study of neurological diseases, including vertebrates and invertebrates.
Animal Models for Neurological Disorders
Animal models connect basic research and clinical transformation, and they mimic disease pathogenesis and development through preclinical research to accelerate drug development, which helps reduce the risk for pharmaceutical companies. Each model has its own advantages and disadvantages, so choosing the right animal model is becoming more and more important in the field of neuroscience research.
Animal models have been of significant impact, offering a wide variety of experimental tools that can potentially address some of the outstanding questions underlying neurological disease. To advance the research of neuroscience, Creative Biolabs now provides a variety of antibodies, proteins, agonists/antagonists, toxins against various targets to meet our clients’ requirements. We also provide one-stop customized preclinical animal modeling services for our clients. If you are interested in our services and products, please do not hesitate to contact us for more detailed information.
