Bell's Palsy Related Research Tools

Bell's palsy is a disorder caused by damage to the facial nerve that supports the muscles of the face. It is also called facial palsy. Bell’s palsy is marked by a droopy appearance on one side of the face and the inability to open or close the eye on the other affected side. Other common symptoms include drooping of one corner of the mouth, difficulty eating and drinking, facial weakness, flattening of the creases and folds in the skin, a sagging lower eyelid, headache and sensitivity to sound.

Bell's palsy occurs due to a malfunction of the facial nerve, cranial nerve VII. Inflammation of the facial nerve may lead to pressure on the nerve, blocking the transmission of neural signals or damaging the nerve. Although the cause of Bell's palsy is unknown, some research shows that the viruses and bacteria may be related to the development of Bell’s palsy (e.g. herpes simplex, HIV, sarcoidosis, herpes zoster virus, Epstein-Barr virus, or Lyme disease, a bacterial infection caused by infected ticks).

Fig.1 Anatomy of the facial nerve: topographic diagnosis.

Creative Biolabs aims to provide biological reagents to help understand the cause and pathophysiology of Bell's palsy. These reagents include but are not limited to monoclonal antibodies, polyclonal antibodies, labeled antibodies, proteins, analytical kits, and small molecule activators and inhibitors.

Biological Processes and Genes Related to Bell's Palsy

Biological Processes	Genes
NOD-like receptor signaling pathway	IFNA1, DEFA3, DEFA1, ANTXR2
Defense response to gram-negative bacterium	DEFA3, DEFA1, CD4
Intracellular estrogen receptor signaling pathway	DEFA3, DEFA1
Mitochondrial fission	PRKN, MX1
Positive regulation of T cell proliferation	IL2RA, CD40LG, CD4
Membrane disruption in other organisms	DEFA3, DEFA1
Defense response to virus	MX1, IFNA1, DEFA3, DEFA1
Defense response	MX1, IFNA1, DEFA3, DEFA1

For Research Use Only. Not For Clinical Use.

Target

Neurofilament L

HOMER1

NT-4

ORP150

Rab5

FABP4

Huntingtin

VCAM1

Engrailed 1

QKI

procollagen type IIA

Ataxin 1

Synaptojanin 1

Fatty Acid Synthase

Sarcoplasmic Reticulum

Hemojuvelin

VRK1

ECEL1

Calretinin

Alpha Internexin

NEFM

NMU

Mint-1

Syntaxin

CD20

GSTP1

FTO

Nogo A

KRIT1

Neuroligin 1

p39

galectin 9/Gal-9

Bell's Palsy Related Research Tools

Biological Processes and Genes Related to Bell's Palsy

Target

The Spectrum of Stem Cell-Based Neuronal Models and Their Fit for Purpose