Product
Naphthalimide-Styrene Fluorophore Probe (HeckGal), Two-Photon Probe
[CAT#: NTC-2102-P01C]
Used for the In Vivo Tracking of Cellular Senescence
- Tracer Type:
- Probe
- Applications:
- Optogenetics
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
Product Overview
Description
Cellular senescence is a stable state of cell cycle arrest, which may have a negative impact on the regeneration ability of tissues, and may lead to the progression of inflammation and various aging-related diseases. Detecting the progress of cellular senescence in vivo is still crucial for monitoring the effects of senescent drugs and assessing the early onset or accumulation of senescent cells.
At CBL, we have developed a naphthalimide-styrene-based probe (HeckGal) to detect cell senescence in vivo and in vitro. HeckGal is hydrolyzed by the increased lysosomal β-galactosidase activity of senescent cells, resulting in fluorescence emission. In all cases, HeckGal can clearly detect aging in vitro and in vivo in tissues and tumors. The fluorophore tool provides a potential technique for detecting aging in aging or damaged tissues.
At CBL, we have developed a naphthalimide-styrene-based probe (HeckGal) to detect cell senescence in vivo and in vitro. HeckGal is hydrolyzed by the increased lysosomal β-galactosidase activity of senescent cells, resulting in fluorescence emission. In all cases, HeckGal can clearly detect aging in vitro and in vivo in tissues and tumors. The fluorophore tool provides a potential technique for detecting aging in aging or damaged tissues.
Tracer Type
Probe
Applications
Optogenetics
Research Areas
Neural Circuit Mapping
Expression
Normal Expression
Properites
Shipping
Viral particles are shipped frozen on dry ice.
Handling Advice
The lentivirus is generally referred to as BSL-2. AAV is usually considered BSL-1, but may require BSL-259 handling depending on the insert.
Storage
Store at -80°C. Thaw just before use and keep on ice.
Quality Control
Creative Biolabs ensures high-quality viral vectors by optimizing and standardizing production plans and implementing strict quality control (QC). The specific QC analysis performed for each virus batch is different.
Titer: The precise titer of the sample will be reported on the test tube. The potency you see on this page is the guaranteed minimum potency.
Titer: The precise titer of the sample will be reported on the test tube. The potency you see on this page is the guaranteed minimum potency.
Research Use Only
For research use only.
Product Pictures
Fig.1 Applications of HeckGal in breast cancer mouse model.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
