Naphthalimide-Styrene Fluorophore Probe (HeckGal), Two-Photon Probe

[CAT#: NTC-2102-P01C]

Used for the In Vivo Tracking of Cellular Senescence

Tracer Type:: Probe

Applications:: Optogenetics

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Product Overview

Description

Cellular senescence is a stable state of cell cycle arrest, which may have a negative impact on the regeneration ability of tissues, and may lead to the progression of inflammation and various aging-related diseases. Detecting the progress of cellular senescence in vivo is still crucial for monitoring the effects of senescent drugs and assessing the early onset or accumulation of senescent cells.

At CBL, we have developed a naphthalimide-styrene-based probe (HeckGal) to detect cell senescence in vivo and in vitro. HeckGal is hydrolyzed by the increased lysosomal β-galactosidase activity of senescent cells, resulting in fluorescence emission. In all cases, HeckGal can clearly detect aging in vitro and in vivo in tissues and tumors. The fluorophore tool provides a potential technique for detecting aging in aging or damaged tissues.

Tracer Type

Probe

Applications

Optogenetics

Research Areas

Neural Circuit Mapping

Expression

Normal Expression

Properites

Shipping

Viral particles are shipped frozen on dry ice.

Handling Advice

The lentivirus is generally referred to as BSL-2. AAV is usually considered BSL-1, but may require BSL-259 handling depending on the insert.

Storage

Store at -80°C. Thaw just before use and keep on ice.

Quality Control

Creative Biolabs ensures high-quality viral vectors by optimizing and standardizing production plans and implementing strict quality control (QC). The specific QC analysis performed for each virus batch is different.

Titer: The precise titer of the sample will be reported on the test tube. The potency you see on this page is the guaranteed minimum potency.