NeuroMab™ Anti-Amyloid Beta 2-40 Amyloid Beta 3-40 APP BBB Shuttle Antibody(NRZP-1022-ZP3652)

[CAT#: NRZP-1022-ZP3652]

Host Species:: Mouse

Species Reactivity:: Human

Applications:: WB; ELISA; In Vitro; IHC

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; ELISA; In Vitro; IHC

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

AmyloidBeta2-40AmyloidBeta3-40APP

Official Name

Amyloid Beta

Full Name

Amyloid Beta

Alternative Names

Aβ; Abeta

Product Pictures

Figure 1 Confirmation of the specificity of the 82E1 antibody by Western Blotting.

Antibody 82E1 does not react with amyloid beta (2-40) and amyloid beta (3-40), but only recognizes amyloid beta (1-40). On the other hand, it was confirmed that the 6E10 antibody does not react with amyloid β(1-40), but recognizes amyloid β(2-40) and amyloid β(3-40).

Figure 2 Confirmation of the specificity of the 82E1 antibody by Western Blotting

It was confirmed that the 82E1 monoclonal antibody does not react with APP, and only recognizes amyloid β and βCTF. On the other hand, it was confirmed that the 6E10 antibody recognized APP.

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