- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- FC; IHC; In Vitro; In Vivo
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Lot Number
SPECIFIC INQUIRY
inquiryDescription
Immunogen
Species Reactivity
Clonality
Host Species
Applications
Relevant Diseases
Formulation
Preservatives
Concentration
Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
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Research Use Only
Figure 1 shows the detection of SEZ6 protein expression in NTX tumor cells by flow cytometry using various anti-SEZ6 antibodies.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Figure 2 shows the results of an in vitro disruption assay using anti-SEZ6 ADCs in HEK293 cells overexpressing SEZ6.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Figure 3 shows the effect of anti-SEZ6 ADCs on the growth of SCLC (LU86) and LCNEC (Lu50) tumors in vivo.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Figure 4 shows the ability of conjugated humanized anti-SEZ6 antibodies to delay the growth of four SCLC tumors (LU80, LU64, LU111 and LU117) in vivo and achieve durable remission in immunosuppressed mice.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Figure 5 shows the ability of conjugated humanized anti-SEZ6 antibodies to delay the growth of four SCLC tumors (LU80, LU64, LU111 and LU117) in vivo and achieve durable remission in immunosuppressed mice.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Publications (0)
ExcellentA fantastic addition to our labWe've used it extensively in our flow cytometry experiments and found it to be highly specific with minimal background noise. The results have significantly improved the quality of our research on neural pathways.
ExcellentHighly recommend it to other researchersThe antibody binds specifically to SEZ6, and we observed robust and reproducible staining. The product has contributed to our understanding of SEZ6's role in neurodevelopment, and we plan to continue using it in future studies.
ExcellentThe antibody provided clear and distinct staining of SEZ6 in brain tissue samplesIts high specificity and low background have made our imaging results very reliable. We are extremely satisfied with the performance of this antibody.
ExcellentWe are very pleased with the resultsThe antibody showed excellent specificity and sensitivity in our mouse models. It has allowed us to visualize SEZ6 expression in a way that was not possible with other antibodies.
ExcellentHigh accuracyWe've used it for both in vitro and in vivo experiments and found it to be highly specific and reliable. The antibody provided consistent and clear results, which has been crucial for our research on neural cell markers.
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