NeuroMab™ Anti-TNFα BBB Shuttle Antibody(NRZP-1022-ZP2702)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Chimeric

Applications

ELISA; Neut; Block; Inhib; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

TNFα

Official Name

TNF-α

Full Name

TNF-alpha

Alternative Names

TNF; DIF; TNF-alpha; TNFA; TNFSF2; Tumour necrosis factor; TNF-α; tumor necrosis factor; TNLG1F; Tumor necrosis factor alpha

Product Pictures

ELISA

Figure 1 is a graph showing the dose-dependent binding of mouse mAb A2 to human TNF[alpha].

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Figure 2 is a graph showing the neutralizing effect of murine A2 on TNF cytotoxicity in vitro.

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Figure 3 shows that mAb A2 inhibits or neutralizes TNF production by chimpanzee monocytes and rhTNF[alpha].

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Figure 4 is a graph showing the neutralizing effect of chimeric A2 on TNF cytotoxicity.

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Figure 5 shows the cross-blocking epitope ELISA results for mouse A2 (mA2).

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Figure 6 is a graph showing the in vitro neutralization of TNF-induced ELAM-1 expression by chimeric A2. Control is chimeric mouse/human IgG1 anti-CD4 antibody.

Publications