Rat Anti-Mouse β Amyloid 1-16 Monoclonal Antibody (CBP3662)

[CAT#: NAB2012428LS]

Anti-β Amyloid 1-16 Monoclonal Antibody [Biotin]

Host Species:: Rat

Species Reactivity:: Mouse

Applications:: WB; IF; ELISA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Request Pricing

Inquiry

Product Overview

Description

Alzheimer's disease is characterized by the accumulation of aggregated Aβ peptides in senile plaques and vascular deposits. Aβ peptides are derived from amyloid precursor proteins (APP) through sequential proteolytic cleavage of APP by β-secretases and γ-secretases generating diverse Aβ species. Aβ can aggregate to form soluble oligomeric species and insoluble fibrillar or amorphous assemblies. Some forms of the aggregated peptides are toxic to neurons.

Immunogen

The epitope has been determined to be within residues 10-15 of murine Aβ.

Species Reactivity

Mouse

Clonality

Monoclonal

Host Species

Rat

Isotype

IgG1, κ

Clone Number

CBP3662

Applications

WB; IF; ELISA

Application Notes

WB (1:500-1:1000); IF (1:1000-1:2000)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Alexa Fluor 594; Alexa Fluor 488; Alexa Fluor 498; Alexa Fluor 647; Alexa Fluor 700; APC; APC/Cyanine 7; APC/Fire 750; Biotin; Brilliant Violet 421; Brilliant Violet 510; Brilliant Violet 570; Brilliant Violet 570; Brilliant Violet 605; Brilliant Violet 650; Brilliant Violet 711; Brilliant Violet 750; Brilliant Violet 785; FITC; HRP; PE; Pacific Blue; PE/Cyanine 5; PE/Cyanine 7; PerCP; Spark YG 570

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

1.0 mg/mL

Purification

Affinity Chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

Amyloid Beta 1-16

Official Name

β Amyloid 1-16

Full Name

Amyloid Precursor Protein

Alternative Names

APP; AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2; amyloid beta precursor protein; preA4

Gene ID

351 (Human); 11820 (Mouse); 54226 (Rat)

Uniprot ID

P05067 (Human); P12023 (Mouse); P08592 (Rat)

References

1. Kumar A, et al. 2015. Pharmacol. Rep. 67(2):195.
2. Sadigh-Eteghad S, et al. 2015. Med. Princ. Pract. 24(1):1.
3. Hampel H, et al. 2015. Expert Rev. Neurother. 15(1):83.
4. Puig KL, Combs CK. 2013. Exp. Gerontol. 48(7): 608.
5. Selkoe DJ, Hardy J. 2016. EMBO Mol. Med. 8(6):595.
6. Walsh DM, Selkoe DJ. 2007. J. Neurochem. 101(5):1172.

Publications