Mouse Anti-Human FGF-4 Monoclonal Antibody (CBP4323)

Product Overview

Description

FGF-4 was first identified as HST-1 gene by a NIH3T3 transforming assay. It belongs to the FGF family that includes 22 members (FGF1-FGF23). However, FGF15 has not been identified in humans. FGF-4 exhibits strong effects on many different cell types and tissues, and plays an important role in both embryogenesis and adult tissue stem cell development in a variety of organisms. FGF-4 can stimulate limb mesenchyme proliferation and can provide all the signals required for normal outgrowth and patterning of the limb. FGF-4 mRNA has been detected in the apical ectodermal ridge of the limb bud in day 11 and 12 embryos. FGF-4 is also involved in early heart development by supporting the proliferation and differentiation of precardiac myoblasts. In adults, FGF-4 is expressed in the testis and its overexpression results in enhanced spermatogenesis.

Immunogen

Partial human FGF-4 recombinant protein (54-206 a.a.) expressed in E. coli.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a, κ

Clone Number

CBP4323

Applications

Application Notes

WB (0.25-1.0 µg/mL)

Relevant Diseases

Brain Tumors; Alzheimer's Disease; Parkinson's Disease; Neurocutaneous Syndromes

Research Areas

Neuroinflammation; Neurodegeneration

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, pH 7.2, containing 0.09% sodium azide.

Concentration

0.5 mg/mL

Purification

Affinity chromatography

Purity

>95%, as determined by Coomassie stained SDS-PAGE.

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the recommended temperature.

Storage

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Handling Advice

Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

FGF4

Official Name

FGF4

Full Name

Fibroblast Growth Factor 4

Alternative Names

Fibroblast Growth Factor 4; Transforming Protein KS3; Human Stomach Cancer; Transforming Factor From FGF-Related Oncogene; Heparin Secretory Transforming Protein 1; Heparin-Binding Growth Factor 4; Kaposi Sarcoma Oncogene; HBGF-4; HSTF-1; HSTF1; FGF-4;