Transgenic C. elegans Models for Alzheimer's Disease
Creative Biolabs offers state-of-the-art services for the development of transgenic Caenorhabditis elegans (C. elegans) models specifically tailored for Alzheimer's Disease (AD) research. By leveraging the genetic tractability and simplicity of C. elegans, Creative Biolabs enables researchers to investigate the complex molecular and cellular mechanisms underlying AD. With expertise in gene design, vector construction, microinjection, and phenotypic analysis, Creative Biolabs provides custom transgenic C. elegans models expressing key AD-related proteins such as beta-amyloid (Aβ) peptides and tau proteins. These models serve as valuable tools for studying AD pathogenesis, identifying therapeutic targets, and advancing our understanding of this devastating neurodegenerative disorder.
Our C. elegans Models for Alzheimer's Disease
Fig.1 AD C. elegans Models. (Alvarez, 2022)
At Creative Biolabs, we have developed a range of transgenic C. elegans models specifically tailored for Alzheimer's disease research. These models incorporate key genetic modifications that mimic various aspects of the disease pathology, allowing researchers to explore disease mechanisms and test potential therapeutic interventions.
- Aβ C. elegans Models
- APOE C. elegans Models
- APP C. elegans Models
- Presenilin C. elegans Models
- Tau C. elegans Models
Our Custom Transgenic C. elegans Model Development Service:
Creative Biolabs offers a specialized service for the development of custom transgenic C. elegans models tailored to AD research. With our extensive experience and expertise, Creative Biolabs' scientists are equipped to design and create models that precisely mimic various aspects of AD pathology and molecular mechanisms. Our custom C. elegans model development service includes:
Gene Design and Vector Construction
Creative Biolabs' team of experts employs state-of-the-art gene design strategies to construct vectors tailored to express AD-related genes or mutations in C. elegans. By utilizing precise genetic engineering techniques, they can generate transgenes with specific regulatory elements and control the expression of target genes in a tissue- or cell-specific manner.
Microinjection and Transgenic Line Generation
The transgenic C. elegans models are developed through microinjection techniques, which involve the precise introduction of transgenes into the nematode's germline. Creative Biolabs utilizes their cutting-edge facilities and equipment to efficiently generate stable transgenic lines. These lines can be propagated and maintained for long-term studies.
Phenotypic Analysis and Functional Studies
To assess the effectiveness of the custom transgenic C. elegans models, Creative Biolabs offers a comprehensive range of phenotypic analysis services. These include locomotion assays, lifespan analysis, behavioral studies, and electrophysiological measurements. These analyses enable the characterization of disease-related phenotypes.
We Provide the Following Benefits:
- We offer cost-effective and time-efficient assays to generate predictivity data before employing rodent models. These assays provide valuable insights without the need for extensive resources or time-consuming processes.
- Our approach yields a rich and sensitive data set that surpasses the limitations of traditional manual lifespan assays. By utilizing advanced techniques, we capture comprehensive information that allows for a deeper understanding of the subject under study.
- Our standardized, population-scale acute and chronic testing procedures enable thorough evaluation of mutation and compound effects on both longevity and fitness. By incorporating a large sample size, we ensure reliable and statistically significant results.
- Our team consists of multidisciplinary experts who are readily available to guide you in study design and data analysis. Their collective knowledge and experience enhance the quality and validity of your research, ensuring robust findings and accurate interpretations.
In addition to offering C. elegans models for Alzheimer's disease, we also provide models for various other neurodegenerative disorders, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), Huntington's disease, Cockayne syndrome, and Autosomal Dominant Optic Atrophy (ADOA).
We are committed to providing our clients with high-quality, reliable, and cost-effective transgenic C. elegans models for Alzheimer's disease research. Please feel free to contact us for more about our C. elegans models related services.
Reference
- Alvarez, J.; Alvarez-Illera, P.; Santo-Domingo, J.; Fonteriz, R.I.; Montero, M. Modeling Alzheimer's Disease in Caenorhabditis elegans. Biomedicines 2022, 10, 288. https://doi.org/10.3390/biomedicines10020288
