Tel:
Fax:
Email:
Creative Biolabs
Product

NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody,Clone NR3861P

[CAT#: NRZP-1022-ZP2534]

Host Species:
Mouse
Species Reactivity:
Human
Applications:
DB; ELISA; FC; IHC; In Vitro

Datasheet MSDS Request COA

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

Inquiry

SPECIFIC INQUIRY

inquiry
Size:
Conjugation:
Endotoxin:
Purity:
Engineering:
Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Clone Number

NR3861P

Applications

DB; ELISA; FC; IHC; In Vitro

Relevant Diseases

Parkinson's Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

AlphaSynuclein

Official Name

SNCA

Full Name

Alpha-synuclein

Alternative Names

SNCA; NACP; PARK1; PARK4; PD1; synuclein alpha
Product Pictures
ELISA

Fig.1 show the results of the inhibition ELISA using the antibody.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

DB

Fig.2 shows the Pepscan results for the mAbs Syn-F1, Syn-F2, Syn-O1, Syn-O2, Syn-O3 and Syn-O4, and Syn-1 antibody (as a control) by dot blot for epitope determination.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

ELISA

Fig.3 show the results of the sandwich ELISA for the detection of phosphorylated Ser129-α-synuclein aggregates.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

IHC

Fig.4 shows the immunhistochemical analysis of tissues from Parkinson's disease.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

FuncS

Fig.5 shows the % of puncta positive cells of each tested antibody.

Rats were treated with intraocular injections of solutions of 3H4 Fab (2.4 pg/eye) compared to Sham or Vehicle controls. Statistical significance is shown.

Publications

Publications (0)

gift-card

Related Products
For Research Use Only. Not For Clinical Use.
Send Inquiry Send Inquiry
Inquiry Basket
compare

Send inquiry