NeuroMab™ Anti-Amyloid Beta 1-42 BBB Shuttle Antibody(NRZP-1022-ZP3666)

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Mouse

Applications

WB; In Vitro; In Vivo

Relevant Diseases

Alzheimer's Disease

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

AmyloidBeta1-42

Official Name

Amyloid Beta

Full Name

Amyloid Beta

Alternative Names

APP; Aβ; Abeta; Amyloid β

Product Pictures

ELISA

Figure 1 illustrates the selectivity of 8C5 for globulomers versus Aß(1-42) monomers, Aß(1-40) and sAPP. The selectivity factor for 8C5 can be calculated as the ratio between EC50 values (relative to Aβ(1-42) monomer in HFIP 2346/568.2=4.1; relative to Aß(1-42) monomer in NH4OH > 100; relative to Aβ (1-40 ) monomer >100; relative to sAPP >100)

FuncS

Figure 2 shows the binding of different concentrations of antibodies to the neocortex cross-sections of Alzheimer's disease (AD) patients or aged APP transgenic mice.

Figure 5 illustrates the quantification of the analysis of Aβ plaque staining in histological images using image analysis. Density values were calculated by subtracting the gray value of the background tissue from the gray value of the plaque (0% = no staining).

Publications