NeuroMab™ Anti-Caspr/paranodin/neurexin IV BBB Shuttle Antibody, Clone K65/35

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-CASPR BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein 1308-1381 (cytoplasmic domain) of rat Caspr (accession number P97846)
Human: 80% identity
Mouse=100% identity

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

K65/35

Applications

WB; IHC; IP; ICC

Research Areas

CAMs

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

CASPR

Official Name

CNTNAP1

Full Name

CASPR/Neurexin IV

Alternative Names

CNTNAP1; CASPR; CNTNAP; NRXN4; P190; contactin associated protein 1; CHN3

Uniprot ID

P97846

Product Pictures

Fig. 1 Adult rat brain membrane immunoblot.

IHC

Fig. 2 Adult rat hippocampus immunohistochemistry.

Fig. 3 Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from Caspr knockout (Caspr KO) and wild-type (WT) mice.

Fig. 4 Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)].

Publications