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Creative Biolabs
Product

NeuroMab™ Anti-FGF13 (Fibroblast growth factor 13) BBB Shuttle Antibody, Clone N91/27

[CAT#: NRZP-0423-ZP101]

Species Reactivity:
Human; Mouse; Rat
Applications:
WB; IHC; IP; ICC

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Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-FGF13 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 53-245 of human FGF13a (also known as fibroblast growth factor homologous factor 2a or FHF2a, accession number Q92913)
Mouse: 99% identity (192/193 amino acids identical)
Rat: 97% identity (183/188 amino acids identical)
97% identity with FGF13b (184/188 amino acids identical)
>60% identity with FGF11, FGF12 and FGF14

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Human; Mouse; Rat

Clonality

Monoclonal

Isotype

IgG1

Clone Number

N91/27

Applications

WB; IHC; IP; ICC

Application Notes

Cross-reacts with FGF13a and FGF13b;Does not cross-react with FGF11, FGF12 or FGF14 expressed in heterologous cells

Conjugation

Unconjugated
Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.
Target

Target

FGF13

Official Name

FGF13

Full Name

FGF13/FHF2

Alternative Names

FGF 13; FGF 2; FGF-13; FGF13; FGF13; FGF2; FHF 2; FHF-2; FHF2; Fibroblast growth factor 13; Fibroblast growth factor homologous factor 2; OTTHUMP00000024143; THUMP00000024144

Uniprot ID

Q92913
Product Pictures
IB

Fig. 1 Transfected cell immunoblot: extracts of whole rat brain homogenate (WBH) and COS cells transfected with GFP-tagged FGF11/FHF3 and FGF13/FHF2 and untagged Kv2.1 plasmids and probed with N91/27 (left) and N52A/42 (right) TC supe.

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For Research Use Only. Not For Clinical Use.
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