Product
NeuroMab™ Anti-GABA-A-R-Gamma2L BBB Shuttle Antibody, Clone N452/69
[CAT#: NRZP-0423-ZP119]
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA A Receptor Gamma 2 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 360-445 (cytoplasmic C-terminus) of human GABA-A-R-Gamma2L (also known as Gamma-aminobutyric acid receptor subunit gamma-2 and GABRG2, accession number P18507-2)
Mouse: 100% identity (86/86 amino acids identical)
Rat: 100% identity (86/86 amino acids identical)
>90% identity with GABA-A-R-Gamma2S (amino acids 377-384, LLRMFSFK, unique to Gamma2L)
>50% identity with GABA-A-R-Gamma1 and GABA-A-R-Gamma3
Mouse: 100% identity (86/86 amino acids identical)
Rat: 100% identity (86/86 amino acids identical)
>90% identity with GABA-A-R-Gamma2S (amino acids 377-384, LLRMFSFK, unique to Gamma2L)
>50% identity with GABA-A-R-Gamma1 and GABA-A-R-Gamma3
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N452/69
Applications
WB; IHC; ICC
Application Notes
Does not cross-react with GABA-A-R-Gamma2S, GABA-A-R-Gamma1 or GABAA-R-Gamma3
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GABA A Receptor Gamma 2
Official Name
GABRG2
Full Name
GABA(A)R, Gamma2L
Alternative Names
GABRG2; CAE2; ECA2; GEFSP3; gamma-aminobutyric acid type A receptor gamma2 subunit; EIEE74; FEB8
Uniprot ID
P18507-2
Product Pictures
IB
Fig. 1 Adult rat brain membrane immunoblot.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
