NeuroMab™ Anti-IL-6 BBB Shuttle Antibody,Clone NR2473P

Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Species Reactivity

Human

Clonality

Monoclonal

Host Species

Chimeric

Clone Number

NR2473P

Applications

WB; Inhib; Neut; In Vitro; In Vivo

Relevant Diseases

Neuroinflammation

Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only

Target

IL-6

Official Name

IL6

Full Name

Interleukin 6 (IL-6)

Alternative Names

IL6; BSF2; HGF; HSF; IFNB2; IL-6; BSF-2; CDF; IFN-beta-2; interleukin 6

Product Pictures

ELISA

Figure 1 shows a graph showing the binding of cCLB8 to human recombinant IL-6.

Inhib

Figure 2 graph showing the inhibition of IL-6-mediated IgM mu secretion from SKW6.4 cells by cCLB8.

Inhib

Figure 3 is a graph showing the inhibition of IL-6-mediated MCP-1 production by cCLB8.

Figure 4. Western blot images showing cCLB8 inhibits IL-6 signaling in THP-1 human monocytic leukemia cells.

Inhib

Figure 5 is a graph showing that cCLB8 inhibits IL-6-induced serum amyloid A production in HepG2 cells.

Neut

Figure 6 is a graph showing the ability of cCLB8 to neutralize rhIL-6-induced cell proliferation.

FuncS

Figure 7 is a graph showing the relative reduction in body weight loss in tumor-bearing mouse hosts treated with anti-human and anti-mouse IL-6 antibodies.

Publications