Product
NeuroMab™ Anti-LRP4 (extracellular) BBB Shuttle Antibody, Clone N207/27
[CAT#: NRZP-0423-ZP245]
- Species Reactivity:
- Mouse; Rat
- Applications:
- WB; IHC; ICC
Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-LRP4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 26-350 (extracellular N-terminus) of mouse LRP4 (also known as Lowdensity lipoprotein receptor-related protein 4, LDLR dan, Multiple epidermal growth factor-like domains 7, MEGF7 and KIAA0816, accession number Q8VI56)
Rat: 98% identity (321/325 amino acids identical)
Human: 97% identity (317/325 amino acids identical)
<50% identity with LRP1
Rat: 98% identity (321/325 amino acids identical)
Human: 97% identity (317/325 amino acids identical)
<50% identity with LRP1
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Mouse; Rat
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N207/27
Applications
WB; IHC; ICC
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
LRP4
Official Name
LRP4
Full Name
LRP4 (extracellular)
Alternative Names
LRP4; CLSS; LRP-4; LRP10; MEGF7; SOST2; CMS17; Low density lipoprotein receptor-related protein 4; LDL receptor related protein 4
Uniprot ID
Q8VI56
Product Pictures
IB
Fig. 1 Adult rat brain membrane immunoblot.
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
