NeuroMab™ Anti-mGluR1/5 (group I) glutamate receptor BBB Shuttle Antibody, Clone N75/3
[CAT#: NRZP-0423-ZP266]
- Species Reactivity:
- Human; Rat; Mouse
- Applications:
- WB; IHC; IP; ICC
Certificate of Analysis Lookup
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-mGluR5 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fusion protein amino acids 824-1203 (cytoplasmic C-terminus) of rat mGluR5b (also known as metabotropic glutamate receptor 5, accession number P31424)
Mouse: 96% identity (368/388 amino acids identical)
Human: 87% identity (339/388 amino acids identical)
<35% identity with mGluR1
Mouse: 96% identity (368/388 amino acids identical)
Human: 87% identity (339/388 amino acids identical)
<35% identity with mGluR1
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
N75/3
Applications
WB; IHC; IP; ICC
Application Notes
Recognizes mGluR1 and mGluR5
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
mGluR5
Official Name
GRM5
Full Name
mGluR1/5 (Group I) glutamate receptor
Alternative Names
GRM5; GPRC1E; MGLUR5; PPP1R86; mGlu5; glutamate metabotropic receptor 5
Uniprot ID
P31424
Product Pictures
IB
Fig. 1 Adult rat brain membrane immunoblot.
IHC
Fig. 2 Adult rat hippocampus immunohistochemistry.
Publications
Publications (0)
Neural Antibodies
For Research Use Only. Not For Clinical Use.
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