NoGeneST™ Anti-mGluR5 Aptamer, amGluR5 aptamer

Name: NoGeneST™ Anti-mGluR5 Aptamer, amGluR5 aptamer
SKU: NRYF-0625-HZ110
Rating: 5 (1 reviews)

[CAT#: NRYF-0625-HZ110]

Aptamer designed to specifically recognize Metabotropic Glutamate Receptor 5, a key modulator of synaptic plasticity and a target for neurological disorders.

Target:: mGluR5

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Product Overview

Relevant Diseases

Autism Spectrum Disorder

Properties

Size

5 nmol. 10 nmol. 50 nmol

Soluble In

PBS; buffer system with Serum; other

Purity

>90%

Shipping

Room temperature

Storage

Powder Form: Stable for 3 years when stored at -20°C.
In Solvent: Stable for 6 months when aliquoted and stored at -80°C

Research Use Only

For Research Use Only

Target Details

Target

mGluR5

Full Name

Metabotropic Glutamate Receptor 5

Gene ID

2915

Uniprot ID

P41594

Target Overview

Metabotropic glutamate receptor 5 (mGluR5) is a G protein-coupled receptor (GPCR) that is activated by the brain's primary excitatory neurotransmitter, glutamate. It is highly expressed at the postsynaptic density of neurons, where it plays a crucial role in modulating long-term synaptic plasticity, learning, and memory. Unlike ionotropic receptors that form ion channels, mGluR5 activation initiates prolonged intracellular signaling cascades that regulate neuronal function. Dysregulation of mGluR5 signaling is implicated in numerous neurological and psychiatric disorders, including Fragile X syndrome, addiction, and anxiety, making it a significant therapeutic target.

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