NeuroMab™ Anti-OPN BBB Shuttle Antibody,Clone NR3367P
[CAT#: NRZP-1022-ZP2605]
- Host Species:
- Human
- Species Reactivity:
- Human; Mouse
- Applications:
- ELISA; Inhib; Neut; In Vitro; In Vivo
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Lot Number
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number
SPECIFIC INQUIRY
inquiryProduct Overview
Description
Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
Human; Mouse
Clonality
Monoclonal
Host Species
Human
Clone Number
NR3367P
Applications
ELISA; Inhib; Neut; In Vitro; In Vivo
Relevant Diseases
Alzheimer's Disease; Neuroinflammation
Product Properties
Storage
Store at -20°C. Do not aliquot the antibody.
Research Use Only
For research use only
Target
Target
SPP1
Official Name
SPP1
Full Name
Secreted phosphoprotein 1
Alternative Names
BNSP;
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;
Bone sialoprotein 1;
Bone sialoprotein I;
BSP I;
BSPI;
Early T lymphocyte activation 1;
ETA 1;
ETA1;
MGC110940;
Nephropontin;
OPN;
Osteopontin;
Product Pictures
FuncS
Fig.1 shows the effect of MOR-6993 on tumor weight in a preclinical model of breast cancer.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
FuncS
Fig.2 shows the effect of MOR-6993 on metastasis in a preclinical model of breast cancer.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
Neut
Fig.3 shows the neutralization of mouse osteopontin by MOR-6990 and MOR-6993.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
Neut
Fig.4 shows the neutralization of human osteopontin by MOR-6990 and MOR-6993.
The data are shown as mean±SE for 8 animals, 7 animals and 5 animals in the control group, 25 mg/kg group and 50 mg/kg group, respectively. *p<0.05, **p<0.01: significantly different from control group as determined by Dunnet's multiple comparison test.
Publications
Publications (0)
Neural Antibodies
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For Research Use Only. Not For Clinical Use.
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