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NeuroMab™ Anti-SORT1 BBB Shuttle Antibody(NRZP-1022-ZP3959)
- Host Species:
- Mouse
- Species Reactivity:
- Human
- Applications:
- In Vitro; In Vivo; Block
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
Species Reactivity
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Relevant Diseases
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Research Use Only
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Figure 1 depicts sortin cell surface expression on human U-251 cells.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3959-1.png)
Figure 2 depicts sortin cell surface expression on mouse N2A cells.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3959-2.png)
Figure 3 depicts the measurement of sorterin levels using Western blot analysis of leukocyte lysates from mice.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3958-8.png)
Figure 4 depicts the results of a collagen-induced arthritis study in mice. Biweekly injection of 40 mg/kg anti-Sortilin antibody S-15-6 significantly reduced clinical arthritis scores compared to controls (PBS and MOPC-21/msIgG1).
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3958-9.png)
Figure 5 depicts progranulin (PGRN) in cerebrospinal fluid (CSF) samples obtained from rats two or six days after intra-articular (ia) injection into the knee or intraperitoneal (ip) injection of anti-sortin antibody S-15 ) protein level-6 or control antibody. n=2 rats/group. **p<0.001 One-way ANOVA.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP3958-10.png)
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