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Creative Biolabs
Product

NeuroMab™ Anti-TREM2 Antibody, Clone NR67P

[CAT#: NRP-0422-P794]

A functional antibody raised against Human, Cynomolgus Monkey TREM2.

Host Species:
Humanized
Species Reactivity:
Human; Cynomolgus Monkey
Applications:
FC; ELISA; In Vitro; Agonist; In Vivo

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Product Overview

Description

The antibody specifically binds a TREM2 protein, e.g., a mammalian TREM2 or human TREM2, and use of such compositions in preventing, reducing risk, or treating an individual in need.

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Humanized

Clone Number

NR67P

Applications

FC; ELISA; In Vitro; Agonist; In Vivo

Relevant Diseases

Alzheimer's Disease
Product Properties

Formulation

PBS only

Preservatives

BSA Free

Concentration

1mg/mL

Purification

Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line

Purity

>95% by SDS PAGE or HPLC

Endotoxin Level

Regular Endotoxin < 5 EU/mg
Low Endotoxin < 1 EU/mg

Shipping

Gel Packs

Storage

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Research Use Only

For research use only
Target

Target

TREM2

Official Name

TREM2

Full Name

Triggering receptor expressed on myeloid cells 2

Alternative Names

TREM2; Triggering receptor expressed on myeloid cells 2

Gene ID

54209(Human)

Uniprot ID

Q9NZC2(Human)
Product Pictures
Agonist

Figure 1 shows the increased agonistic activity of Fc variant anti-TREM2 antibodies. Luciferase activity of Fc variant antibodies co-cultured with BWZ reporter cells and THP-1 cells at a ratio of 1:1 for 6 hours.

Agonist

Figure 2 shows the increased agonistic activity of Fc variant anti-TREM2 antibodies. Luciferase activity after 6 hours incubation with Fc variant of anti-TREM2 antibody.

FuncS

Figure 3 shows C3b deposition induced by Fc variant anti-TREM2 antibodies. Fold change in C3b deposition on HEK expressing TREM2 cell lines of AL2p Fc variants relative to human IgG1 isotype control antibody at 10 μg/mL.

FuncS

Figure 4 shows C3b deposition induced by Fc variant anti-TREM2 antibodies. Fold change in C3b deposition of AL2p affinity matured variants with the listed Fc mutations relative to their parental IgG1 Fc variants.

FuncS

Figure 5 shows the increase in activity of soluble anti-TREM2 antibody.

FuncS

Figure 6 shows the increased activity of soluble anti-TREM2 antibodies.

FuncS

Figure 7 shows sTREM2 secreted by primary human dendritic cells from donor 534 within 48 hours of incubation with anti-TREM2 or control antibody.

FuncS

Figure 8 shows that after incubation of primary human dendritic cells from donor 534 with anti-TREM2 or control antibody, there was no change in cell number.

FuncS

Figure 9 shows plasma sTREM2 as a percentage of baseline levels following a single injection of 15 mg/kg of the TREM2 antibodies AL2p-47 huIgG1 , AL2p-47 huIgG1 ASPSEG, AL2p-58 huIgG1 , or control huIgG1.

FuncS

Figure 10 depicts increased viability (increased cellular ATP) after stimulation of primary human macrophages.

WB

Figure 11 shows Western blot analysis of Dapl2 phosphorylation in WT or TREM2 Bac-Tg mouse peritoneal macrophages treated with AL2p-58 huIgG1 , AL2p-58 huIgG1 PSEG or control huIgG1.

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