AAV-Ef1α -DIO-PSAM4-5HT3 HC-IRES-EGFP

Name: AAV-Ef1α -DIO-PSAM4-5HT3 HC-IRES-EGFP
SKU: NRYF-0624-HZ19
Rating: 5 (1 reviews)

[CAT#: NRYF-0624-HZ19]

Neuron activation

Tracer Type:: Chemogenetics

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Product Overview

Description

The synthetic chemogenetic channel PSAM4-5HT3-HC was created by fusing a mutated α7-nicotinic acetylcholine receptor (engineered to bind the antismoking drug Varenicline at subtherapeutic concentrations) with the ion pore-domain of the 5HT3 (serotonin receptor 3A).
It has the cation-selective conductivity characteristics of 5HT3 receptors. When activated by the agonist varenicline, it causes the cell membrane to depolarize and form an action potential.

Tracer Type

Chemogenetics

Functional Gene

PSAM4-5HT3

Virus Type

Adeno-Associated Virus (AAV)

Promoter

Ef1α

Expression

Cre-dependent

Properites

Color

Green

Fluorophore

EGFP

Shipping

Dry ice

Storage

-80°C

Research Use Only

For research use only

References

Magnus, Christopher J et al. "Ultrapotent chemogenetics for research and potential clinical applications." Science (New York, N.Y.) vol. 364,6436 (2019): eaav5282. doi:10.1126/science.aav5282IF: 44.7 Q1

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