AAV-Ef1α -DIO-PSAM4-5HT3 HC-IRES-EGFP
[CAT#: NRYF-0624-HZ19]
Neuron activation
- Tracer Type:
- Chemogenetics
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SPECIFIC INQUIRY
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Description
The synthetic chemogenetic channel PSAM4-5HT3-HC was created by fusing a mutated α7-nicotinic acetylcholine receptor (engineered to bind the antismoking drug Varenicline at subtherapeutic concentrations) with the ion pore-domain of the 5HT3 (serotonin receptor 3A).
It has the cation-selective conductivity characteristics of 5HT3 receptors. When activated by the agonist varenicline, it causes the cell membrane to depolarize and form an action potential.
It has the cation-selective conductivity characteristics of 5HT3 receptors. When activated by the agonist varenicline, it causes the cell membrane to depolarize and form an action potential.
Tracer Type
Chemogenetics
Functional Gene
PSAM4-5HT3
Virus Type
Adeno-Associated Virus (AAV)
Promoter
Ef1α
Expression
Cre-dependent
Properites
Color
Green
Fluorophore
EGFP
Shipping
Dry ice
Storage
-80°C
Research Use Only
For research use only
References
References
Magnus, Christopher J et al. "Ultrapotent chemogenetics for research and potential clinical applications." Science (New York, N.Y.) vol. 364,6436 (2019): eaav5282. doi:10.1126/science.aav5282IF: 44.7 Q1
Publications
Publications (0)
Neural Tracers
For Research Use Only. Not For Clinical Use.
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