Brain Ischemia/Hemorrhage/Stroke Modeling and Drug Efficacy Testing Service

Disease Mechanism

Cerebrovascular accidents are divided into two categories: hemorrhagic and ischemic. Brain hemorrhage is non-traumatic hemorrhage of the brain parenchyma (brain hemorrhage, subarachnoid hemorrhage). Brain ischemia is focal cerebral ischemia and infarction caused by insufficient blood supply or interruption of blood flow.

Modeling

Assays after Modeling

Creative Biolabs offers a variety of well-accepted behavioral tests to assess potential anxiolytic, antidepressant, or antipsychotic effects, as well as cognitively enhancing and disruptive effects on learning and memory (cognitive, psychiatric, neurological). We have developed a comprehensive range of rat primary neuronal culture models and assays to evaluate the neurotoxic, neuroprotective or neurotrophic effects of test compounds (cellular models).

1) TTC staining is used to determine the volume of cerebral infarction

2) Longa scoring method, Garcia scoring method or Bederson scoring method, etc.

In additon to the above tests, we also provide MRI/PET-CT in vivo imaging of small animals, cardiac ultrasound, X-ray films, tissue fluorescence imaging (whole brain slide scan, tissue immunofluorescence imaging), patch clamp on cells and brain slices, multi-channel in vivo electrophysiological recordings, respiration recordings, behavioral testing of pain, anxiety, depression, olfactory function-related (go/no-go) in awake animals.

Why Creative Biolabs?

With extensive research experience, Creative Biolabs also helps our clients validate and develop the most cost-effective experimental designs and protocols. According to your target indications we can establish a screening program for your drug project. In-house expertise allows us to assist you in most CNS and PNS disorders. If you are interested in our service, please do not hesitate to contact us for more details.