Neurological Disease Modeling and Drug Efficacy Testing Service

The most common neurological diseases include Alzheimer's disease, Parkinson's disease, Huntington's disease, pain, stroke, anxiety, depression, etc. To fight against these diseases is currently an extensive focus in the fields. It is important when developing a drug that it should not only be safe but also effective. Combining years of experience and expertise in the field, Creative Biolabs can support your neuroscience research by offering efficacy testing services to identify the safest and most effective compounds.

Model Options

A popular efficacy testing method is to test a compound using animal models for specific diseases. We offer pre-existing models or custom animal model development services to meet your research needs.

Assay Options

From end to end, Creative Biolabs also provides efficacy testing assay development services to accelerate the drug discovery for the treatment of these devastating neurological disorders.

Behavioral studies

• Learning and memory
• Motor function
• Anxiety-like behavior
• Depression-like behavior
• Schizophrenia/bipolar-like behavior
• Drug addictive behavior
• Pain-related behavior
• Homecage behavior and environmental enrichment.

Pharmacological/molecular/biochemical assay

• Distribution and quantitative analysis of gene expression at the mRNA and protein levels
• In vivo and in vitro ligand binding/incorporation assays: receptor binding assays, autoradiography
• Regional brain administration (stereotaxic microinjection) and chronic brain regional administration (osmotic micropump microinfusion)
• Spatiotemporal epigenetic analysis: histone modifications, DNA methylation, and genome-wide DNA methylation profiling.
• Microdialysis

Histological/morphological studies

• Gross brain morphometry
• Colorimetric staining
• Immunostaining
• Adult neurogenesis
• Dendritic spine/synapse morphology
• Subcellular fraction

We always strive for the highest data quality, consistency, and maximal efficiency. Please feel free to contact us for more details.