Neurological Disease Modeling and Drug Efficacy Testing Service

The most common neurological diseases include Alzheimer's disease, Parkinson's disease, Huntington's disease, pain, stroke, anxiety, depression, etc. To fight against these diseases is currently an extensive focus in the fields. It is important when developing a drug that it should not only be safe but also effective. Combining years of experience and expertise in the field, Creative Biolabs can support your neuroscience research by offering efficacy testing services to identify the safest and most effective compounds.

Model Options

A popular efficacy testing method is to test a compound using animal models for specific diseases. We offer pre-existing models or custom animal model development services to meet your research needs.

Neurodegenerative Diseases Models

Alzheimer's Disease (AD)
Parkinson's Disease (PD)
Amyotrophic lateral sclerosis (ALS)

Pain

Acute inflammatory pain
Post surgery pain
Chronic inflammatory pain
Acute nociception
Chronic neuropathic pain
Fibromyalgia-like pain

Psychiatric Models

Anxiety
Depression
Schizophrenia

Other Disease Models

Multiple Sclerosis
Epilepsy
Stroke
Aging Related Diseases
Osteoporosis, etc.

Assay Options

From end to end, Creative Biolabs also provides efficacy testing assay development services to accelerate the drug discovery for the treatment of these devastating neurological disorders.

Behavioral studies

Learning and memory
Motor function
Anxiety-like behavior
Depression-like behavior
Schizophrenia/bipolar-like behavior
Drug addictive behavior
Pain-related behavior
Homecage behavior and environmental enrichment.

Pharmacological/molecular/biochemical assay

Distribution and quantitative analysis of gene expression at the mRNA and protein levels
In vivo and in vitro ligand binding/incorporation assays: receptor binding assays, autoradiography
Regional brain administration (stereotaxic microinjection) and chronic brain regional administration (osmotic micropump microinfusion)
Spatiotemporal epigenetic analysis: histone modifications, DNA methylation, and genome-wide DNA methylation profiling.
Microdialysis

Histological/morphological studies