Gene Therapy Tools

Creative Biolabs is a supplier of products designed for use in neuroscience research. We offer a variety of neuroscience research tools and services, covering areas such as basic research, neurological diseases, neural cell culture, and neural model construction. After extensive product development, we are pleased to announce the launch of several new tools for gene silencing and expression. Our products will assist you in achieving your research objectives, whether you are looking to knock out, knock in, knock down, or overexpress your target.

We are always expanding the product list. Please contact us and tell us your requirements and we'll customize the products according to your needs.

Product Overview

Advances in genome engineering, from the study of disease mechanisms to drug development, are enabling researchers to make unprecedented breakthroughs in neurological disorders. Our selection comprises, but is not restricted to:

RNAi Substrates: We provide three types of small RNAs for RNAi: short hairpin RNA (shRNA), small interfering RNA (siRNA), and microRNA (miRNA). Creative Biolabs offers an extensive selection of products for many popular targets in neurological disorders, such as APOE, Tau, SOD1, CTNNB1, Huntingtin and others. We can also tailor RNAi solutions to match your specific requirements.
Gene Expression Vectors: With our ready-to-use expression vectors, you can skip the time-consuming cloning, validation, and sequence analysis steps. We provide an array of expression systems, promoter clones, fusion tags and screening markers, and you can customize or purchase pre-made, ready-to-use expression vectors.
Antisense Oligonucleotides (ASOs): We now have a list of ready-to-use ASO products for research into a number of neurological disorders. If you have identified a prospective RNA target and are looking for the best ASO, we can provide a customized solution.
Viral Tracers: Viral products play a pivotal role in gene therapy, particularly as gene delivery vectors. By engineering viruses to remove their pathogenicity while preserving their delivery capabilities, viral vectors have become a cornerstone of gene therapy.
MicroRNAs (miRNAs): As critical regulators in neurogenesis and synaptic plasticity, miRNAs are key targets for neurological research. We offer a complete suite of tools including mimics, inhibitors, and in vivo-ready agomirs/antagomirs to precisely manipulate miRNA activity and study their roles in diseases like Alzheimer's and Parkinson's.
Circular RNAs (circRNAs): These exceptionally stable RNA molecules are highly enriched in the brain and are emerging as key players in synaptic function and neurodegeneration. We provide cutting-edge solutions, including custom synthesis and advanced LNP-encapsulated circRNAs, to explore their potential as novel biomarkers or therapeutic agents.
Aptamers: Often termed 'chemical antibodies,' these oligonucleotides can be engineered to bind with high affinity to challenging neurological targets such as Tau aggregates and amyloid-beta plaques. We develop custom aptamers for use as robust diagnostic probes, imaging agents, or therapeutic inhibitors, offering a stable alternative to traditional antibodies.

RNAi Substrates Gene Expression Vectors Antisense Oligonucleotides Viral Tracers MicroRNAs Circular RNAs Aptamers

Advantages

Strict quality control and cost-effective.
Available on request for flexible synthesis sizes and bulk orders.
Cover several kinds of targets for neurological disorders.

Trending Products

Alzheimer's Disease

Cat#	Product Name	Target
NV-2106-P27	ABCA1 Antisense Oligonucleotide (AK311445)	ABCA1
NEP-0421-R0053	App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged	App
NEP-0421-R0232	Human apolipoprotein E (APOE) (NM_000041) ORF clone, Untagged	APOE
NEP-0421-R0140	Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged	PSEN1
NV-2106-P29	Tau Antisense Oligonucleotide (IONIS-MAPTRx)	Tau

Parkinson's Disease

Cat#	Product Name	Target
NEP-0521-R0864	Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged	SNCA
NEP-0621-R0133	Mouse Parkinson disease (autosomal recessive, early onset) 7 (Park7) (NM_020569) clone, Untagged	PARK7
NEP-0621-R0041	Rat Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) (NM_020093) ORF clone/lentiviral particle, Myc-DDK Tagged	PARK2

Amyotrophic Lateral Sclerosis

Cat#	Product Name	Target
NEP-0521-R0748	Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged	SOD1
NEP-0521-R0808	Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged	SOD3
NEP-0521-R0832	Lenti of Human TAR DNA binding protein (TARDBP) (NM_007375) ORF clone, mGFP Tagged	TARDBP
NV-2106-P14	Mouse SOD1 shRNA Silencing Adenovirus	SOD1

Huntington's Disease

Cat#	Product Name	Target
NEP-0521-R0497	Human huntingtin (HTT) (NM_002111) ORF clone, Myc-DDK Tagged	HTT
NEP-0521-R0676	Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged	HAP1

For Research Use Only. Not For Clinical Use.

Target

Aptamer Products

APOE4

CCL2

DRD2

HepG2 Cells

MOG

IL-6

CD63

GRIN2A

PDGF-B

Aβ

Parkin

Thrombin

GRN

ErbB-2

tPA

C4A

SOD1

NCL

CCKBR

α-Synuclein

IL-23

EPCAM

BDNF

TREM2

Glioblastoma Cells

MUC1

VEGF

FV/Va

GABRA1

TRPM2

RNAi Substrates

BCL2L1

PPIB

ADAM17

Ataxin 3

Huntingtin

SOD1

CTNNB1

Expression Vectors

Optineurin

HAP1

S100 Beta

Clusterin

DN-IκB

IL-1α

NQO1

CA-IKK

Myelin Basic Protein

Parkin

HIP14

Synphilin 1

Alpha Synuclein

PGP9.5

Kallikrein 6

Huntingtin

Alpha B Crystallin

APPBP2

Apo E

SOD1

HTT

PARK7

SETD2

Il-1β

NSE

APP

PACRG

BACE2

SOD3

AP2A2

KCNIP1

TDP43

Antisense Oligonucleotides (ASOs)

FUS

HBV

DNM2

Ha-Ras

PTP-1B

NLRP3

CMV

ApoE

BACE1

PPMO

PCSK9

TTR

HIF1A

IRS1

PKK

TGF-β2

ABCA1

APOC3

CRP

UBE3A

TREM2

GFAP

GHR

Grb2

C-Raf

SMAD7

Tau

LRRK2

SNCA

CD49d

PARK7

TNF-α

Related Products

Target: GFAP

NoGeneST™ Gene Silencing siRNA Kit, Gfap (Human/Mouse/Rat) [CAT#: NRYF-0625-XY941]

Under standard conditions, at least one siRNA pair achieved an mRNA silencing efficiency exceeding 70%.

Applications:: Gene Silencing

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