NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody, Clone 5C1H4
- Host Species:
- Humanized
- Species Reactivity:
- Human
- Applications:
- FuncS
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Figure 1 shows the results of passive immunotherapy using 5C1 on the memory performance of the probe portion of the Morris water maze test.
Figure 2 shows the results of passive immunotherapy using 5C1 for speed and error in the round beam test.
Figure 3 shows the results of an ELISA assay testing the affinity of different humanized 5C1 antibodies.
Figure 4 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of α-synuclein bound by the 9E4 antibody.
The upper part of the panel shows the protein of full-length α-synuclein (wild-type or individual point mutations of residues 118-126, as indicated) stained with the 9E4 antibody (left panel) or the control antibody 1H7 (right panel). blot. The lower part of the figure shows the epitope of α-synuclein bound by the 9E4 antibody.
Figure 5 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of [alpha]-synuclein to which the 5C1 antibody binds.
The upper part of the panel shows full-length α-synuclein (wild-type or a single point mutation in residues 118-126, as indicated) stained with the 5C1 antibody (left panel) or the control antibody 1H7 (right panel). Western blot. The lower part of the figure shows the epitope of α-synuclein bound by the 5C1 antibody.
Figure 6 shows the results of an alanine scanning mutagenesis experiment used to determine the epitope of α-synuclein bound by the 5D12 antibody.
Figure 7 depicts a ball-and-stick model of the amino acids of α-synuclein near the binding site of the 9E4, 5C1 and 5D12 antibodies.
