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NeuroMab™ Anti-Alpha Synuclein BBB Shuttle Antibody, Clone NR52P
- Host Species:
- Rabbit
- Species Reactivity:
- Human
- Applications:
- DB; ELISA; FC; IHC; In Vitro; Cyt; In Vivo
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.
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Fig.1 Alpha-synuclein staining in brain stem of an alpha-synuclein[A30P]-transgenic mouse.
Fresh frozen 10 μm sagittal brain sections; 40× magnification; all images at identical illumination conditions; arrowheads indicate Lewy neurite-like inclusions.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP2557-1.png)
Fig.2 Staining of antibodies 0017 and 0018 in human brain cortex of a Parkinson's Disease patient.
(A), an Alzheimer's Disease patient with Parkinson's Disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); arrow: Lewy-body like inclusions; arrowhead: Lewy neurite-like inclusions.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP2557-2.png)
Fig.3 Cellular toxicity of conditioned media from recombinant alpha-synuclein from SHSY5Y cells on LUHMES cells.
(A), an Alzheimer's Disease patient with Parkinson's Disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); arrow: Lewy-body like inclusions; arrowhead: Lewy neurite-like inclusions.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP2557-3.png)
Fig.4 The antibody is able to immunodeplete alpha-synuclein oligomers from extracellular media and thereby these antibodies reduce toxicity of alpha-synuclein oligomers.
(A), an Alzheimer's Disease patient with Parkinson's Disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); arrow: Lewy-body like inclusions; arrowhead: Lewy neurite-like inclusions.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP2557-4.png)
Fig.5 Labeling of brain alpha-synuclein pathology, vasculature, and parenchyma in alpha-synuclein mutant A30P transgenic mice upon acute peripheral injection of an anti-alpha synuclein-antibody-blood-brain-barrier shuttle module conjugate.
(A), an Alzheimer's Disease patient with Parkinson's Disease comorbidity (B) and progressive supranuclear palsy (PSP, tauopathy) (C); arrow: Lewy-body like inclusions; arrowhead: Lewy neurite-like inclusions.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP2557-5.png)
Fig.6 Confocal microscopy analysis of immunohistochemically analyzed cryosections of Parkinson's Disease patient's brain sections (identical setting for all images).
(A) antibody 0017, (B) antibody 0018.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP2557-6.png)
Fig.7 Binding of monomeric (N-terminally free (1) and N-terminally His-tagged (2)) and dimeric (3) alpha-synuclein to antibody 0018.
The results shown are a titration of 5 concentrations.
1: monomer, free N-terminus, 4.2 mg/mL, never thawed;
2: monomer, His-tagged N-terminus, 4.8 mg/mL;
3: dimer, free N-terminus, 1.6 mg/mL.
![](https://img.creative-biolabs.com/neuros/productImages/NRZP-1022-ZP2557-7.png)
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