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Creative Biolabs
Product

NeuroMab™ Anti-ApoC3 BBB Shuttle Antibody,Clone NR1794P

[CAT#: NRZP-1022-ZP3504]

Host Species:
Human
Species Reactivity:
Human; Cynomolgus Monkey
Applications:
WB; ELISA; Inhib; In Vitro; In Vivo; Antagonist

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Product Overview

Description

Brain uptake of therapeutic antibodies is severely limited by their size. To achieve enhanced BBB crossing, Creative Biolabs developed a BBB shuttle antibody platform by utilizing the endogenous macromolecule transportation pathway, known as receptor-mediated transcytosis (RMT). The engineered antibody-based carrier is believed to significantly to increase the macromolecule brain entry to combat CNS diseases.
Notes: The BBB antibody is made-to order and available in a customized format. Please don't hesitate contact us for more details.

Immunogen

Human ApoC3 (huApoC3) protein

Species Reactivity

Human; Cynomolgus Monkey

Clonality

Monoclonal

Host Species

Human

Isotype

IgG

Clone Number

NR1794P

Applications

WB; ELISA; Inhib; In Vitro; In Vivo; Antagonist

Relevant Diseases

Alzheimer's Disease
Product Properties

Storage

Store at -20°C. Do not aliquot the antibody.

Research Use Only

For research use only
Target

Target

ApoC3

Official Name

ApoC3

Full Name

Apolipoprotein C-III

Alternative Names

APOC3; APOCIII; HALP2; apolipoprotein C3
Product Pictures
ELISA

Figure 1 is a graph showing the interference of ApoC3 antibodies on the binding of ApoC3 to dimyristoylphosphatidylcholine (DMPC).

ELISA microplates were coated with DMPC and incubated with ApoC3 and test anti-ApoC3 antibodies. Measure the amount of ApoC3 still attached to the plate using a biotinylated anti-ApoC3 polyclonal goat antibody following standard procedures for ELISA colorimetric assays.

SPR

Figure 2 shows the binding of ApoC3 to VLDL in the presence of anti-ApoC3 antibody.

FuncS

Figure 3 is a graph showing that 14C7 and 13G7 attenuate the ability of ApoC3 to inhibit lipoprotein lipase (LPL) activity. 1

4C7, 13G7, 5E5, or 646 antibodies were incubated with lipid emulsion and purified ApoC3 protein. The production of non-esterified fatty acids (NEFA) was measured and the percentage of NEFA produced compared to that produced by ApoC3 but in the absence of anti-ApoC3 antibody was plotted.

FuncS

Figure 4 is a set of graphs showing that certain anti-ApoC3 antibodies attenuate the ability of ApoC3 to inhibit very low density lipoprotein (VLDL) uptake by HepG2 cells.

ELISA

Figure 5 shows antibody binding to human ApoC3 (huApoC3) or cvnomolgus monkey ApoC3 (cynoApoC3).

ELISA

Figure 6 shows acceleration of ApoC3 and ApoB clearance from blood following subcutaneous injection of 6A6 antibody to mice expressing human ApoC3.

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For Research Use Only. Not For Clinical Use.
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