- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- FC; IHC; In Vitro; In Vivo
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Lot Number
SPECIFIC INQUIRY
inquiryDescription
Species Reactivity
Clonality
Host Species
Applications
Relevant Diseases
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Preservatives
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Purification
Purity
Endotoxin Level
Low Endotoxin < 1 EU/mg
Shipping
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Research Use Only
Figure 1 shows the detection of SEZ6 protein expression in NTX tumor cells by flow cytometry using various anti-SEZ6 antibodies.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Figure 2 shows the results of an in vitro disruption assay using anti-SEZ6 ADCs in HEK293 cells overexpressing SEZ6.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Figure 3 shows the effect of anti-SEZ6 ADCs on the growth of SCLC (LU86) and LCNEC (Lu50) tumors in vivo.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Figure 4 shows the ability of conjugated humanized anti-SEZ6 antibodies to delay the growth of four SCLC tumors (LU80, LU64, LU111 and LU117) in vivo and achieve durable remission in immunosuppressed mice.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Figure 5 shows the ability of conjugated humanized anti-SEZ6 antibodies to delay the growth of four SCLC tumors (LU80, LU64, LU111 and LU117) in vivo and achieve durable remission in immunosuppressed mice.
Axis corresponds to concentration of 3E antibody (Fab) and Y axis corresponds to NGF binding (percentage of maximal UR). Increasing concentrations of Fab E3 blocked the interaction of NGF with p75 and trkA, as indicated by a decrease in signal (measured in UR). When the concentration of E3 antibody (Fab) was equal to that of NGF, no NGF binding was observed (indicated by zero signal).
Publications (0)
ExcellentPerformed exceptionally well in our in vivo studiesWe needed an antibody that could specifically target SEZ6 in live tissue, and this one did not disappoint. The staining was robust and specific, allowing us to track SEZ6 expression in real-time effectively.
ExcellentThis antibody helped us identify significant findings in our SEZ6-related researchI conducted a series of in vitro experiments using the antibody and was very pleased with the results. The antibody showed high affinity and specificity for SEZ6, and we observed minimal background staining.
ExcellentThis antibody worked wonderfullyThe staining was very specific, with no cross-reactivity, and the signal was strong even at low concentrations. We used it to study SEZ6 expression in various brain regions, and the results were clear and reproducible.
ExcellentWe used the antibody in our flow cytometry experiments and found it to be highly specific and reliableThe antibody provided consistent results across multiple samples and experiments. The clear distinction between SEZ6-positive and SEZ6-negative cells was impressive, making our data analysis straightforward.
ExcellentIt was easy to use and produced reproducible resultsIt demonstrated high specificity and affinity for SEZ6, allowing us to achieve clear, consistent results in our assays. This antibody has become a crucial tool in our research on SEZ6 function and expression.
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