Mouse Anti-APP Monoclonal Antibody (CBP2673)

[CAT#: NAB20101747CR]

Mouse Monoclonal (5C2A1) to ABETA

Host Species:: Mouse

Species Reactivity:: Human; Porcine

Applications:: IHC; WB; ELISA

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Product Overview

Description

Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver.

Expression Host

Mammalian cells

Immunogen

Beta Amyloid fusion protein Ag0769

Species Reactivity

Human; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2a

Clone Number

CBP2673

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Growth and Development

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

1120 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

ABeta

Official Name

ABETA

Full Name

Amyloid beta (A4) precursor protein

Alternative Names

A4; AAA; ABETA; ABPP; AD1; AICD 50; AICD 57; AICD 59; AID(50); AID(57); AID(59); Amyloid beta A4 protein; amyloid P; APP

Gene ID

351(Human); 11820(Mouse)

Uniprot ID

P05067(Human); P12023(Mouse)

References

1. Nishida, N., Yoshida, K., & Hata, Y. (2017). Sudden unexpected death in early Parkinson's disease: neurogenic or cardiac death?. Cardiovascular Pathology, 30, 19-22. 2. Zhou, C., Sun, X., Hu, Y., Song, J., Dong, S., Kong, D.,... & Jin, G. (2019). Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease. Aging (Albany NY), 11(17), 7257. 3. Shentu, Y. P., Huo, Y., Feng, X. L., Gilbert, J., Zhang, Q., Liuyang, Z. Y.,... & Wang, J. Z. (2018). CIP2A Causes Tau/APP phosphorylation, synaptopathy, and memory deficits in Alzheimer's disease. Cell reports, 24(3), 713-723.

Publications