Mouse Anti-TLR4 Monoclonal Antibody (CBP2752)

Product Overview

Description

TLR4 belongs to the Toll-like receptor family. TLR4 interacts with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). TLR4 acts via MYD88, TIRAP and TRAF6, leading to NF-kB activation, cytokine secretion and the inflammatory response. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

Expression Host

Mammalian cells

Immunogen

TLR4 fusion protein Ag13857

Species Reactivity

Human; Mouse; Rat; Porcine

Clonality

Monoclonal

Host Species

Mouse

Isotype

IgG2b

Clone Number

CBP2752

Applications

IHC; WB; ELISA

Application Notes

IHC : 1:20-1:200; WB : 1:500-1:1000

Research Areas

Neurotransmitter

Conjugation

Unconjugated

Product Properties

Form

Liquid

Formulation

PBS, 0.1% sodium azide and 50% glycerol pH 7.3.

Preservatives

Yes

Concentration

773 μg/ml

Purification

Antigen affinity purification

Purity

>95%, as determined by SDS-PAGE

Shipping

The product is shipped at 4°C. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store at -20°C. Stable for one year after shipment.

Research Use Only

For research use only, not for diagnostic or therapeutic use.

Target

CD284

Official Name

TLR4

Full Name

Toll-like receptor 4

Alternative Names

ARMD10; CD284; hToll; TLR4; TOLL; toll like receptor 4

Gene ID

7099(Human); 21898(Mouse); 29260(Rat)

Uniprot ID

Q9QUK6(Human); Q9QX05(Mouse)

References

1. Zhang, K., Yang, R., Chen, J., Qi, E., Zhou, S., Wang, Y.,... & Fang, X. (2020). Let-7i-5p Regulation of Cell Morphology and Migration Through Distinct Signaling Pathways in Normal and Pathogenic Urethral Fibroblasts. Frontiers in Bioengineering and Biotechnology, 8, 428. 2. Pang, Y., Zhao, Y., Wang, Y., Wang, X., Wang, R., Liu, N.,... & Li, J. (2020). TNFAIP8 promotes AML chemoresistance by activating ERK signaling pathway through interaction with Rac1. Journal of Experimental & Clinical Cancer Research, 39(1), 1-18.

Publications