Schizophrenia Modeling and Drug Efficacy Testing Service

Disease Mechanism

Schizophrenia is a group of chronic diseases of unknown etiology, mostly in young adults with slow or subacute onset, and clinically often manifested as a syndrome with different symptoms, involving various disorders such as perception, thinking, emotion, and behavior. Incoordination of mental activity. The patients are generally conscious and their intelligence is normal, but some patients may experience cognitive impairment in the course of the disease.

Schizophrenia Modeling

1) Studies have found that injections of NMDA receptor antagonist drugs in humans can cause behavioral manifestations similar to schizophrenia symptoms, including hallucinations, delusions, and bizarre behavior. Likewise, injections of such drugs in rodents have shown psychotic-like behavioral changes, such as sensorimotor gating disorders, hyperactivity, social withdrawal, and learning and memory dysfunction. Representative drugs of NMDA receptor antagonists include ketamine, PCP, and MIA-801.

2) Using a series of methods to damage some special brain areas of neonatal rats, such as the prefrontal cortex, hippocampus, and amygdala, because these brain areas play an important role in cognition and emotion in the brain, the damage to these areas simulates the mental state to some extent. Manifestations of schizophrenia. The earliest study is the ventral hippocampus of neonatal rats. The injury model destroys the extensive cortical and subcortical neural circuits involved in the hippocampus, resulting in schizophrenia-like manifestations. At present, this model is quite mature. The most rapidly developing model is the excitotoxic injury model of the basolateral amygdala in neonatal rats. This model has increased movement, increased auditory startle response, deficits in prepulse inhibition (PPI) of the startle reflex, and sustained latent inhibition. (LI) Abnormal, cognitive decline such as spatial learning ability and memory.

Assays after Modeling

1) Cognitive function testing

2) Active Avoidance Response (AAR)

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