Calcium-activated Potassium Channels
Calcium-activated potassium channels (KCa channels), or calcium-gated potassium channels, are a unique family of ion channels for their activation by intracellular Ca2+. They directly transmit calcium signals to transmit changes in cell membrane potential required for cellular processes, including but not limited to cell proliferation and migration.
KCa channels are divided into three main variants, which are mainly expressed in the nervous system and are insensitive to voltage, that is, controlled only by the increase of intracellular Ca2+. Although all three types of KCa channels are regulated by intracellular Ca2+, their biophysical and pharmacological characteristics are different. Large-conductance calcium-activated potassium (BKCa) channels are known for their ability to regulate vascular tone. Small-conductance calcium-activated potassium (SK) channels are widely expressed in the nervous system, and they are involved in regulating the firing frequency of many neurons, including nociceptive neurons. On the other hand, the intermediate-conductance calcium-activated potassium (IKCa) channels are considered not to exist in the normal brain, but they have been described in many cancer cells that are related to growth control.
Creative Biolabs provides a variety of products for potassium channel receptors research, including monoclonal antibodies, labeled antibodies, proteins, assay kits, and small molecule activators and inhibitors.
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