Voltage-Gated Calcium Channel Related Research Reagents

The voltage-gated calcium channel (VGCC) is a key sensor that converts membrane potential into intracellular Ca²⁺ transients and can be excited in the membrane of cells, such as muscles, glial cells, and neurons. At physiological or resting membrane potential, VGCC is usually turned off. They open channels under depolarized membrane potential and allow calcium ions to flow into the cell. Calcium channels mediate calcium influx in response to membrane depolarization, triggering many physiological events in many different cell types, such as contraction, secretion, neurotransmission, and gene expression. Their activity is essential for coupling electrical signals on the cell surface with physiological events of the cell. Excessive activation of VGCC is a major component of excitotoxicity, where a serious increase in intracellular calcium levels will activate the respective enzymes, which, in response, will degrade the necessary cellular structure at a level above thresholds.

Fig.1 Voltage-gated calcium channels mediate numerous physiological functions. (Yuen, 2017)

Creative Biolabs provides a variety of calcium channel blockers, which can prevent calcium ions from passing through the channels on the cell membrane, and are used to treat hypertension and epilepsy. Our product portfolio also includes a series of products for calcium channel receptors research, including monoclonal antibodies, labeled antibodies, proteins, assay kits, and small molecule activators and inhibitors.

Please browse the options to take a deeper look at the tools for your research needs.

Reference

1. Yuen, S.; et al. Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proceedings of the National Academy of Sciences. 2017, 114(45), E9520-E9528.

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Mouse Anti-TARP Gamma2/4/8 (CBP2120) [CAT#: NAB2007FY789]

Mouse Monoclonal [W0050] to CACNG2/Stargazin

Host Species:

Mouse

Species Reactivity:

Human; Mouse; Rat

Applications:

WB; ICC; IF

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated

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Mouse Anti-Cav3.1 Monoclonal Antibody (CBP2102) [CAT#: NAB2007FY765]

Mouse Monoclonal [NS178A-9] to Cav3.1

Host Species:

Mouse

Species Reactivity:

Human; Mouse; Rat

Applications:

WB; ICC; IF

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated

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Mouse Anti-Cav beta 4 Monoclonal Antibody (CBP2101) [CAT#: NAB2007FY764]

Mouse Monoclonal [NS10-7] to Cav beta 4

Host Species:

Mouse

Species Reactivity:

Hamster; Human; Mouse; Rat

Applications:

WB; IHC; ICC; IF; IP; AM

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated

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Mouse Anti-Cav beta 1 Monoclonal Antibody (CBP2100) [CAT#: NAB2007FY763]

Mouse Monoclonal [NS7-18] to Cav beta 1

Host Species:

Mouse

Species Reactivity:

Human; Mouse; Rat

Applications:

WB; IHC; ICC; IF; IP; AM

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated

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Mouse Anti-Kv3.1 Monoclonal Antibody (CBP2058) [CAT#: NAB2007FY706]

Mouse Monoclonal [NS16B-8] to Kv3.1

Host Species:

Mouse

Species Reactivity:

Human; Mouse; Rat

Applications:

WB; IHC; ICC; IF; AM

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 594; PerCP; RPE; Streptavidin; Unconjugated

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Mouse Anti-Cav1.3 Monoclonal Antibody (CBP2033) [CAT#: NAB2007FY678]

Mouse Monoclonal [NS38-8] to Cav1.3

Host Species:

Mouse

Species Reactivity:

Human; Mouse; Rat

Applications:

WB; IHC; ICC; IF; IP; AM

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated

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Mouse Anti-Cav1.3 Monoclonal Antibody (CBP2032) [CAT#: NAB2007FY677]

Mouse Monoclonal [NS48A-9] to Cav1.3

Host Species:

Mouse

Species Reactivity:

Human; Mouse; Rat

Applications:

WB; IHC; ICC; IF; IP; AM

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated

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Mouse Anti-Cav1.2 Monoclonal Antibody (CBP2031) [CAT#: NAB2007FY676]

Mouse Monoclonal [NS57-46] to Cav1.2

Host Species:

Mouse

Species Reactivity:

Hamster; Human; Mouse; Rat

Applications:

WB; IHC; ICC; IF; IP; AM

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated

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Mouse Anti-Cav beta 2 Monoclonal Antibody (CBP2030) [CAT#: NAB2007FY675]

Mouse Monoclonal [NS8B-1] to Cav beta 2

Host Species:

Mouse

Species Reactivity:

Human; Mouse; Rat

Applications:

WB; IHC; ICC; IF; IP; AM

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 604; PerCP; RPE; Streptavidin; Unconjugated

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Datasheet MSDS

Mouse Anti-Cav3.2 Monoclonal Antibody (CBP1993) [CAT#: NAB2007FY590]

Mouse Monoclonal [NS55-10] to Cav3.2

Host Species:

Mouse

Species Reactivity:

Human; Mouse; Rat

Applications:

WB; IHC; ICC; IF; IP; AM

Conjugation:

Alkaline Phosphatase; APC; APC/Cy7; ATTO 390; ATTO 488; ATTO 565; ATTO 594; ATTO 633; ATTO 655; ATTO 680; ATTO 700; Biotin; Dylight 350; Dylight 405; Dylight 488; Dylight 594; Dylight 633; FITC; HRP; PE/ATTO 594; PerCP; RPE; Streptavidin; Unconjugated

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Datasheet MSDS