Voltage-Gated Calcium Channel Related Research Reagents

The voltage-gated calcium channel (VGCC) is a key sensor that converts membrane potential into intracellular Ca2+ transients and can be excited in the membrane of cells, such as muscles, glial cells, and neurons. At physiological or resting membrane potential, VGCC is usually turned off. They open channels under depolarized membrane potential and allow calcium ions to flow into the cell. Calcium channels mediate calcium influx in response to membrane depolarization, triggering many physiological events in many different cell types, such as contraction, secretion, neurotransmission, and gene expression. Their activity is essential for coupling electrical signals on the cell surface with physiological events of the cell. Excessive activation of VGCC is a major component of excitotoxicity, where a serious increase in intracellular calcium levels will activate the respective enzymes, which, in response, will degrade the necessary cellular structure at a level above thresholds.
Fig.1 Voltage-gated calcium channels mediate numerous physiological functions. (Yuen, 2017)
Creative Biolabs provides a variety of calcium channel blockers, which can prevent calcium ions from passing through the channels on the cell membrane, and are used to treat hypertension and epilepsy. Our product portfolio also includes a series of products for calcium channel receptors research, including monoclonal antibodies, labeled antibodies, proteins, assay kits, and small molecule activators and inhibitors.
Please browse the options to take a deeper look at the tools for your research needs.
Reference
- Yuen, S.; et al. Structural insights into binding of STAC proteins to voltage-gated calcium channels. Proceedings of the National Academy of Sciences. 2017, 114(45), E9520-E9528.


Mouse Monoclonal to CACNG2/Stargazin
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; ICC; IF
- Conjugation:
- Unconjugated

Mouse Monoclonal to Cav3.1
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; ICC; IF
- Conjugation:
- Unconjugated

Mouse Monoclonal to Cav beta 4
- Host Species:
- Mouse
- Species Reactivity:
- Hamster; Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; IP; AM
- Conjugation:
- Unconjugated

Mouse Monoclonal to Cav beta 1
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; IP; AM
- Conjugation:
- Unconjugated

Mouse Monoclonal to Kv3.1
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; AM
- Conjugation:
- Unconjugated

Mouse Monoclonal to Cav1.3
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; IP; AM
- Conjugation:
- Unconjugated

Mouse Monoclonal to Cav1.3
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; IP; AM
- Conjugation:
- Unconjugated

Mouse Monoclonal to Cav1.2
- Host Species:
- Mouse
- Species Reactivity:
- Hamster; Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; IP; AM
- Conjugation:
- Unconjugated

Mouse Monoclonal to Cav beta 2
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; IP; AM
- Conjugation:
- Unconjugated

Mouse Monoclonal to Cav3.2
- Host Species:
- Mouse
- Species Reactivity:
- Human; Mouse; Rat
- Applications:
- WB; IHC; ICC; IF; IP; AM
- Conjugation:
- Unconjugated
- iNeuMab™ Anti-Alpha Synuclein Antibody (NRP-0422-P614) (Cat#: NRP-0422-P614)
- iNeuMab™ Anti-ApoC3 BBB Shuttle Antibody (NRZP-1022-ZP3503) (Cat#: NRZP-1022-ZP3503)
- iNeuMab™ Anti-ApoC3 BBB Shuttle Antibody (NRZP-1022-ZP3505) (Cat#: NRZP-1022-ZP3505)
- iNeuMab™ Anti-GARP Antibody (NRP-0422-P1639) (Cat#: NRP-0422-P1639)
- iNeuMab™ Anti-Alpha Synuclein BBB Shuttle Antibody (NRZP-1022-ZP4050) (Cat#: NRZP-1022-ZP4050)
- iNeuMab™ Anti-Tau Antibody (NRP-0422-P2275) (Cat#: NRP-0422-P2275)
- iNeuMab™ Anti-FGFR1 Antibody (NRP-0422-P1244) (Cat#: NRP-0422-P1244)
- Mouse Anti-SCN5A Monoclonal Antibody (CBP708) (Cat#: NAB-0720-Z2720)
- iNeuMab™ Anti-Amyloid Beta 1-15 Antibody (NRP-0422-P867) (Cat#: NRP-0422-P867)
- Mouse Anti-Human α-Synuclein Phospho (Tyr39) (CBP3706) (Cat#: NAB201250LS)
- Rat Muller Cell (Cat#: NCL2110P040)
- Human Brain Vascular Adventitial Fibroblasts (Cat#: NCL-21P6-014)
- Human Blood Brain Barrier Model (Cat#: NCL-2103-P187)
- iNeu™ Human Oligodendrocyte Progenitor Cells (OPCs) (Cat#: NCL-2103-P49)
- Rat Glioma Cell Line C6 (Cat#: NCL2110P346)
- Rat Olfactory Ensheathing Cells (Cat#: NRZP-1122-ZP162)
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- Mouse Retinal Ganglion Cell Line RGC-5 (Cat#: NCL2110P154)
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- Beta Amyloid (1-40), Aggregation Kit (Cat#: NRZP-0323-ZP199)
- Alpha Synuclein Aggregation Kit (Cat#: NRZP-1122-ZP15)
- Amyloid beta 1-42 Kit (Cat#: NRP-0322-P2170)
- Human GFAP ELISA Kit [Colorimetric] (Cat#: NPP2011ZP383)
- Human Tau Aggregation Kit (Cat#: NRP-0322-P2173)
- Beta Amyloid (1-42), Aggregation Kit (Cat#: NRZP-0323-ZP200)
- Human Poly ADP ribose polymerase,PARP Assay Kit (Cat#: NRZP-1122-ZP62)
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- Dextran, NHS Activated (Cat#: NRZP-0722-ZP124)
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- Human superoxide dismutase 1, soluble (SOD1) (NM_000454) ORF clone, TurboGFP Tagged (Cat#: NEP-0521-R0748)
- Human presenilin 1 (PSEN1), transcript variant 2 (NM_007318) ORF clone, TurboGFP Tagged (Cat#: NEP-0421-R0140)
- Human huntingtin-associated protein 1 (HAP1) transcript variant 2 (NM_177977) ORF clone, Myc-DDK Tagged (Cat#: NEP-0521-R0676)
- App Rat amyloid beta (A4) precursor protein (App)(NM_019288) ORF clone, Untagged (Cat#: NEP-0421-R0053)
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- Human superoxide dismutase 3, extracellular (SOD3) (NM_003102) ORF clone, Untagged (Cat#: NEP-0521-R0808)
- Mouse SOD1 shRNA Silencing Adenovirus (Cat#: NV-2106-P14)
- Lenti of Mouse synuclein, alpha (Snca) transcript variant (NM_001042451) ORF clone, mGFP Tagged (Cat#: NEP-0521-R0864)
- NeuroBiologics™ Human Cerebrospinal Fluid (Cat#: NRZP-0822-ZP491)
- NeuroBiologics™ Mouse Cerebrospinal Fluid (Cat#: NRZP-0822-ZP497)
- NeuroBiologics™ Monkey Cerebrospinal Fluid (Cat#: NRZP-0822-ZP495)
- NeuroBiologics™ Rat Cerebrospinal Fluid (Cat#: NRZP-0822-ZP496)
- NeuroBiologics™ Pig Cerebrospinal Fluid (Cat#: NRZP-0822-ZP498)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP501)
- NeuroPro™ Anti-idursulfase BBB Shuttle Protein (Cat#: NRZP-0423-ZP497)
- NeuroPro™ Anti-TNFR BBB Shuttle Protein (Cat#: NRZP-0423-ZP510)
- NeuroPro™ Anti-GDNF BBB Shuttle Protein (Cat#: NRZP-0423-ZP500)
- NeuroPro™ Anti-PON1 BBB Shuttle Protein (Cat#: NRZP-0423-ZP507)
- NeuroPro™ Anti-IDS BBB Shuttle Protein (Cat#: NRZP-0423-ZP503)
- NeuroPro™ Anti-ASA BBB Shuttle Protein (Cat#: NRZP-0423-ZP504)
- NeuroPro™ Anti-EPO BBB Shuttle Protein (Cat#: NRZP-0423-ZP508)
- NeuroPro™ Anti-IDUA BBB Shuttle Protein (Cat#: NRZP-0423-ZP498)
- NeuroPro™ Anti-Erythropoietin BBB Shuttle Protein (Cat#: NRZP-0423-ZP499)