Voltage-gated Potassium Channels
Voltage-gated potassium channels (VGKCs) are potassium-specific transmembrane channels with K+ selective pores that are opened by membrane depolarization. VGKCs belong to a diverse and highly evolutionary conserved ion channel family. They are sensitive to voltage changes in cell membrane potential.
Highlighted Functions of VGKCs
- Broadly promote the electrical properties of neurons.
- Help shape the post-synaptic potential. They are the main determinants of the repolarization of action potentials that determine the shape and frequency of spikes.
- Their voltage-dependent activity ensures a non-ohmic current-voltage relationship, thereby enabling the channels to promote the nonlinear characteristics of neurons.
- Have similar functions in other excitatory cells, including all types of muscles.
- Contribute to resting potential and regulate the entry and secretion of Ca2+ in non-excitable cells.
- For excitatory cells such as nerve cells, cardiomyocytes and muscles, the VGKC channel regulates the action potential waveform and emission pattern.
- Regulate cell volume, proliferation and migration of many cell types.
Creative Biolabs provides a variety of products for potassium channel receptors research, including monoclonal antibodies, labeled antibodies, proteins, assay kits, and small molecule activators and inhibitors.
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