CNS/Neurodegeneration Transporter Assay

The study of central nervous system (CNS) disorders and neurodegeneration is of paramount importance in the field of neuroscience. Researchers and pharmaceutical companies are constantly striving to develop novel therapeutics to combat these debilitating conditions. To accelerate drug discovery and gain a deeper understanding of disease mechanisms, reliable and efficient transporter assays are essential. Creative Biolabs, a leading company in the field of biomedical research, offers state-of-the-art CNS/Neurodegeneration Transporter Assays to support the scientific community in their quest for new treatments and insights.

Transport Assays: Unlocking the Secrets of Cellular Transport

Dysfunction or dysregulation of transporters proteins has been implicated in a wide range of neurological disorders, including Alzheimer's disease, Parkinson's disease, and depression. Transport assays provide a valuable tool for evaluating the activity and specificity of these transporter proteins.

At Creative Biolabs, we offer a comprehensive evaluation of transporter proteins. This assay system allows for the quantification of transporter activity, determination of substrate specificity, and assessment of the effect of potential drug candidates on transporter function.

Assays:

• Uptake transporter assays
• Efflux transporter assays
• Substrate binding assays
• Inhibition screening
• Radioactive flux detection
• Fluorescence detection
• Electrophysiology assay
• Vesicular transport assay

Features

Functional Characterization

Cell-based assays offer the ability to assess the functional effects of compounds on cellular systems, providing valuable insights into their activity and mechanism of action.

Coverage of Key Transporters

These assays can evaluate the interaction of compounds with key transporters, such as efflux pumps. or uptake transporters, which play a crucial role in drug disposition and pharmacokinetics.

Availability of Various Panels

Cell-based assays provide the flexibility to choose from a variety of panels, including specific cell lines or tissues, to mimic the relevant biological context and assess compound activity in a more targeted manner.

Customized Screening Project

Cell-based assays can be tailored to meet specific project requirements, enabling the design of customized screening strategies to address unique research questions or target specific pathways or cellular processes.

Monoamine Transporter Panel: Shedding Light on Neurotransmitter Imbalances

The Monoamine Transporter Panel can be tailored to specific requirements, enabling the investigation of specific transporters such as the serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET). By studying the interaction between drug candidates and these transporters, researchers can assess the potential therapeutic benefits and risks associated with their compounds.

Drug Transporters Panel: Assessing Pharmacokinetic Properties

Pharmacokinetic properties play a crucial role in determining the efficacy and safety of drug candidates. Creative Biolabs' Drug Transporters Panel offers a comprehensive evaluation of drug transporters involved in the absorption, distribution, metabolism, and excretion (ADME) of therapeutic compounds. This full panel includes seven (7) FDA transporters panel such as P-glycoprotein (P-gp), breast cancer resistance protein (BCRP), and organic anion-transporting polypeptides (OATPs).

Other Transporters: Unveiling Novel Targets and Mechanisms

In addition to monoamine and drug transporters, Creative Biolabs' CNS/Neurodegeneration Transporter Assays encompass a wide range of other transporters associated with CNS disorders and neurodegeneration. These include glutamate transporters, GABA transporters, amino acid transporters, and ATP-binding cassette (ABC) transporters.

Creative Biolabs offers an extensive collection of transporters, encompassing a wide range of major families. For a comprehensive list of functionally validated transporters, please feel free to contact us for more information.