
- Species:
- Human
- Applications:
- High Throughput Screening
- Cell Types:
- Hippocampal Neuron; Spheroid
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Lot Number
SPECIFIC INQUIRY
inquiryDescription
Creative Biolabs's Human iPSC-Derived Hippocampal Spheroids are derived from induced pluripotent stem cells (iPSC) without integration under fully defined neural induction conditions.
Creative Biolabs's Human iPSC-Derived Hippocampal Spheroids are rich in hippocampal neurons and express zinc finger and BTB domain-containing protein 20 (ZBTB20) and Prospero homeobox protein 1 (PROX1). In addition, the hippocampal neurons derived from the APP variant HS exhibit profound transcriptome changes, which can be regulated by the overexpression of NeuroD1 (ND1), leading to the upregulation of genes whose gene products are related to synaptic transmission and are altered in AD.
Cell Types
Applications
Application Notes
2.hiPSC-derived HSs can be used to model Alzheimer disease
3.hiPSC-derived HSs can be used to develop innovative therapeutic solutions
Relevant Diseases
Species
Cell Purity
Cell Viability
Mycoplasma Testing
Sterility Testing
Genetic Stability Testing
Handling Advice
Growing cells: Growing cell cultures should be checked on receipt using an inverted microscope. Immediately check the cell density upon arrival for any obvious defects. If the cell density is too high (more than 80% confluent) subculture the cells (harvest and reseed) immediately.
For detailed instructions on the thawing procedure of frozen cells and the culture of adherent or suspended cells, please feel free to contact us by email or phone.
Research Use Only
Warnings
Quality Control
Publications (0)
ExcellentThe spheroids are easy to work with, and the results are both reproducible and reliableThe consistency across batches is remarkable, allowing us to obtain reliable and reproducible data. These spheroids closely mimic the in vivo environment, making them an invaluable tool for our drug discovery projects.
ExcellentThe data quality is excellentThey maintained their 3D architecture throughout our long-term culture, which is crucial for our neurotoxicity studies. The results we obtained were consistent and aligned with our in vivo models.
ExcellentWe’ve seen a significant improvementThese spheroids have significantly improved the efficiency of our high throughput screening. The human hippocampal spheroids provided a robust model for assessing neuroprotective compounds, allowing us to screen a large number of candidates in a relatively short time.
ExcellentThe reproducibility between experiments is excellentThe human hippocampal spheroids are a fantastic model for studying neurodegenerative diseases. We used them to assess the effects of various compounds on synaptic health, and the data we collected was highly reliable. The spheroids responded well to treatments, making our experiments much more predictive.
ExcellentA significant advantage over traditional 2D culturesThey replicate the complexity of human brain tissue very well, providing a more physiologically relevant model compared to traditional 2D cultures.
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