iNeuMab™ Anti-GABA-A-R-Beta2/3 BBB Shuttle Antibody (NRZP-0423-ZP115)
[CAT#: NRZP-0423-ZP115]
- Species Reactivity:
- Human; Rat; Mouse
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SPECIFIC INQUIRY
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Description
The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-GABA(A)R, Beta2/3 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.
Immunogen
Fraction of bovine brain GABA-A receptor affinity purified against immobilized benzodiazepine Ro7-1986/1. Target initially identified as a GABA-A receptor by:
-rat brain immunocytochemistry staining pattern via light microscopy identical to that seen via ligand autoradiography with 3H-muscimol
-immunoprecipitation of 3H-muscimol-binding activity of the purified receptor complex
-recognition of ~57 kDa protein in immunoblots against crude rat brain membrane fractions
Binding epitope identified to be within amino acids 26-40 (QSVNDPGNMSFVKET, extracellular N-terminus) of human GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta3, accession number P28472)
Mouse: 100% identity (15/15 amino acids identical)
Rat: 100% identity (15/15 amino acids identical)
86% identity (13/15 amino acids identical, QSVNDPSNMSLVKET) with GABA-A-R-Beta2
66% identity (10/15 amino acids identical, HSTNEPSNMSYVKET) with GABA-A-R-Beta1
-rat brain immunocytochemistry staining pattern via light microscopy identical to that seen via ligand autoradiography with 3H-muscimol
-immunoprecipitation of 3H-muscimol-binding activity of the purified receptor complex
-recognition of ~57 kDa protein in immunoblots against crude rat brain membrane fractions
Binding epitope identified to be within amino acids 26-40 (QSVNDPGNMSFVKET, extracellular N-terminus) of human GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta3, accession number P28472)
Mouse: 100% identity (15/15 amino acids identical)
Rat: 100% identity (15/15 amino acids identical)
86% identity (13/15 amino acids identical, QSVNDPSNMSLVKET) with GABA-A-R-Beta2
66% identity (10/15 amino acids identical, HSTNEPSNMSYVKET) with GABA-A-R-Beta1
Construction
We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.
Species Reactivity
Human; Rat; Mouse
Clonality
Monoclonal
Isotype
IgG1
Conjugation
Unconjugated
Product Properties
Research Use Only
For reseaech use only, not for human or dignostic use.
Target
Target
GABA(A)R, Beta2/3
Official Name
GABA(A)R, Beta2/3
Full Name
GABA(A)R, Beta2/3
Alternative Names
GABRB2; GABRB3
Publications
Publications (0)
For Research Use Only. Not For Clinical Use.
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