iNeuMab™ Anti-GABA-A-R-Beta2/3 (CBP8216)

Immunogen

Fraction of bovine brain GABA-A receptor affinity purified against immobilized benzodiazepine Ro7-1986/1. Target initially identified as a GABA-A receptor by:
-rat brain immunocytochemistry staining pattern via light microscopy identical to that seen via ligand autoradiography with 3H-muscimol
-immunoprecipitation of 3H-muscimol-binding activity of the purified receptor complex
-recognition of ~57 kDa protein in immunoblots against crude rat brain membrane fractions
Binding epitope identified to be within amino acids 26-40 (QSVNDPGNMSFVKET, extracellular N-terminus) of human GABA-A-R-Beta3 (also known as Gamma-aminobutyric acid receptor subunit beta3, accession number P28472)
Mouse: 100% identity (15/15 amino acids identical)
Rat: 100% identity (15/15 amino acids identical)
86% identity (13/15 amino acids identical, QSVNDPSNMSLVKET) with GABA-A-R-Beta2
66% identity (10/15 amino acids identical, HSTNEPSNMSYVKET) with GABA-A-R-Beta1

Species Reactivity

Human; Rat; Mouse

Clonality

Monoclonal

Isotype

IgG1

Clone Number

CBP8216

Applications

WB; IHC; IP; ICC

Conjugation

Unconjugated

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

GABA(A)R, Beta2/3

Official Name

GABA(A)R, Beta2/3

Full Name

GABA(A)R, Beta2/3

Alternative Names

GABRB2; GABRB3