Name: iNeuMab™ Anti-Npas4 BBB Shuttle Antibody (NRZP-0423-ZP306)
SKU: NRZP-0423-ZP306
Rating: 5 (1 reviews)

Product Overview

Description

The BBB is a highly selective membrane that surrounds the blood vessels in the brain, and it can prevent many molecules, including potentially life-saving drugs, from entering the brain. The anti-NPAS4 BBB Shuttle Antibody is designed to bind to receptors on the surface of cells in the BBB, and once bound, the antibody can cross the BBB and into the brain. This technology has the potential to revolutionize the treatment of brain disorders by enabling drugs to reach the brain more effectively.

Immunogen

Fusion protein amino acids 597-802 (C-terminus) of rat Npas4 (also known as Neuronal PAS domain-containing protein 4, Neuronal PAS4, Class E basic helix-loop-helix protein 79, HLHPAS transcription factor NXF, PAS domain-containing protein 10, Limbic-enhanced PAS protein, bHLHe79, PASD10 and LE-PAS, accession number Q8CJH6)
Mouse: 99% identity (205/206 amino acids identical)
Human: 93% identity (193/206 amino acids identical)
<25% identity with other PAS domain-containing proteins

Construction

We offer several options for BBB shuttle antibody design. Antibody construction can be customized according to customer requirements.

Species Reactivity

Rat; Mouse

Clonality

Monoclonal

Isotype

IgG2b

Conjugation

Unconjugated

Product Properties

Research Use Only

For reseaech use only, not for human or dignostic use.

Target

NPAS4

Official Name

NPAS4

Full Name

Npas4

Alternative Names

Neuronal PAS domain-containing protein 4 Antibody, Neuronal PAS4 Antibody, Class E basic helix-loop-helix protein 79 Antibody, HLH-PAS transcription factor NXF Antibody, PAS domain-containing protein 10 Antibody, Limbic-enhanced PAS protein Antibody, bHLHe79 Antibody, PASD10 Antibody and LE-PAS Antibody; Neuronal PAS Domain Protein 4; Class E Basic Helix-Loop-Helix Protein 79; HLH-PAS Transcription Factor NXF; PAS Domain-Containing Protein 10; Neuronal PAS4; BHLHe79